45158-94-9

Basic information

• Product Name: N-METHACRYLOYL-L-LYSINE
• Synonyms: N-METHACRYLOYL-L-LYSINE
• CAS NO: 45158-94-9
• Molecular Formula: C10H18N2O3
• Molecular Weight: 214.26
• Mol File: 45158-94-9.mol

Chemical Properties

• Boiling Point: 455.5 °C at 760 mmHg
• Flash Point: 229.3 °C
• Appearance: /
• Density: 1.109 g/cm³
• CAS DataBase Reference: N-METHACRYLOYL-L-LYSINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-METHACRYLOYL-L-LYSINE(45158-94-9)
• EPA Substance Registry System: N-METHACRYLOYL-L-LYSINE(45158-94-9)

Safety Data

• Hazardous Substances Data: 45158-94-9(Hazardous Substances Data)

Usage

Uses

Used in Tissue Engineering:
N-Methacryloyl-L-lysine is used as a cross-linking agent for the production of hydrogels, which serve as scaffolds to support cell growth and tissue regeneration.
Used in Drug Delivery Systems:
N-Methacryloyl-L-lysine is used as a component in the synthesis of peptide-based materials, which can be employed to create drug delivery systems with enhanced biocompatibility and controlled release properties.
Used in Biomedical and Biotechnological Applications:
N-Methacryloyl-L-lysine is used as an ingredient in the development of advanced biomaterials, leveraging its biocompatibility and ability to mimic the natural cellular environment for various applications in the medical and biotech industries.

Upstream product

• 760-93-0 methacryloyl anhydride 
• 26124-78-7 (S)-α-lysine hydrochloride 
• 920-46-7 Methacryloyl chloride 
• 657-27-2 L-Lysine hydrochloride 

Relevant articles and documents

Polymeric hydrogels modified with ornithine and lysine: Sorption and release of metal cations and amino acids

A novel, convenient synthesis, using copper ions, is described for the multigram-scale preparation of acryloyl and methacryloyl ornithine and lysine without the need to use protecting groups and chromatographic purifications. Three methods of removing the

Synthesis of pro-prodrugs l-lysine based for 5-aminosalicylic acid and 6-mercaptopurine colon specific release

The aim of this work is to design, prepare and characterize l-lysine based prodrugs capable of targeting 6-mercaptopurine to the colon, an anti-tumor and immunosuppressant drug, and 5-aminosalicylic acid (5-ASA), drug of choice for inflammatory bowel disease (IBD). More specifically, Nε-feruloyl-S-(6- purinyl)-l-lysine and Nε-acryloyl-S-(6-purinyl)-l-lysine were synthesized and then characterized by FT-IR, 1H-NMR and GC/MS spectroscopies. The ability of feruloyl derivative in inhibiting lipid peroxidation in rat liver microsomal membranes, induced in vitro by tert-butyl hydroperoxide as source of free radicals, was evaluated. Moreover, Nε-acryloyl-S-(6-purinyl)-l-lysine, polymerizable prodrug, was used to microspheres realization for 5-ASA release. These lasts, obtained by emulsion inverse technique, were characterized by light scattering and scanning electron microscopy (SEM) analysis. The microspheres equilibrium swelling degree was evaluated and showed good swelling behaviour in simulating colonic fluids. Results confirm the possibility that the application range of l-lysine prodrug can be extended to the treatment of intestinal diseases whose conventional therapy envisages medications with serious side effects that, thanks to this new strategy, can be minimized in an optimal way.