452304-63-1

Basic information

• Product Name: (1S,2S)-2-(Diphenylphosphino)-1-aminocyclohexane, min. 97%
• Synonyms: (1S,2S)-2-(Diphenylphosphino)-1-aminocyclohexane, min. 97%;(1S,2S)-2-(Diphenylphosphino)cyclohexylaMine;(1S,2S)-(+)-2-(Diphenylphosphino)cyclohexylaMine, 97+%;(1S,2S)-2-(Diphenylphosphino)cyclohexanamine;(1S,2S)-2-(Diphenylphosphino)cyclohexylamine 95%;(1S,2S)-2-diphenylphosphanylcyclohexan-1-amine;(1S,2S)-2-(Diphenylphosphino)cyclohexylamine 95%
• CAS NO: 452304-63-1
• Molecular Formula: C₁₈H₂₂NP
• Molecular Weight: 283.347741
• Product Categories: Chiral Phosphine
• Mol File: 452304-63-1.mol

Chemical Properties

• Melting Point: 51-56°C
• Boiling Point: 402.9±38.0 °C(Predicted)
• Flash Point: >110℃
• Appearance: white/solid
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 9.87±0.70(Predicted)
• Sensitive: air sensitive
• CAS DataBase Reference: (1S,2S)-2-(Diphenylphosphino)-1-aminocyclohexane, min. 97%(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,2S)-2-(Diphenylphosphino)-1-aminocyclohexane, min. 97%(452304-63-1)
• EPA Substance Registry System: (1S,2S)-2-(Diphenylphosphino)-1-aminocyclohexane, min. 97%(452304-63-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 452304-63-1(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis Industry:
(1S,2S)-2-(Diphenylphosphino)-1-aminocyclohexane, min. 97% is used as a catalyst for various chemical reactions, such as hydrogenation and polymerization, due to its ability to coordinate with transition metal ions and its effectiveness in controlling the stereochemistry of reactions.
Used in Asymmetric Catalysis:
In the field of asymmetric catalysis, (1S,2S)-2-(Diphenylphosphino)-1-aminocyclohexane, min. 97% is utilized as a chiral ligand to facilitate the synthesis of enantiomerically pure compounds. Its rigid cyclohexane backbone and diphenylphosphino group contribute to its ability to control the stereochemistry of reactions, making it a valuable compound for the advancement of chemical synthesis processes.

Upstream product

• 829-85-6 diphenylphosphane 
• 286-20-4 cyclohexane-1,2-epoxide 
• 286-18-0 7-azabicyclo[4.1.0]heptane 

Downstream Products

• 1023287-35-5 C₅₁H₅₄N₃OPS 
• 1314102-50-5 (2R,3R,4S,5R,6R)-2-(acetoxymethyl)-6-(3-((1S,2S)-2-(diphenylphosphino)cyclohexyl)thioureido)-tetrahydro-2H-pyran-3,4,5-triyl triacetate 
• 1314102-52-7 (2R,3S,4S,5R,6R)-2-(acetoxymethyl)-6-(3-((1S,2S)-2-(diphenylphosphino)cyclohexyl)thioureido)-tetrahydro-2H-pyran-3,4,5-triyl triacetate 
• 1314102-54-9 (2R,3R,4S,5S,6S)-2-(acetoxymethyl)-6-(3-((1S,2S)-2-(diphenylphosphino)cyclohexyl)thioureido)-tetrahydro-2H-pyran-3,4,5-triyl triacetate 
• 1619940-70-3 N-[(1S,2S)-2-(diphenylphosphino)cyclohexsyl]-N'-(2,3,4,2',3',4',6'-hexa-O-acetyl-β-D-melibiose)urea 
• 1619940-69-0 N-[(1S,2S)-2-(diphenylphosphino)cyclohexsyl]-N‘-(2,3,6,2‘,3‘,4‘,6‘-hexa-O-acetyl-β-D-lactose) urea 
• 1619940-65-6 N-[(1S,2S)-2-(Diphenylphosphino)cyclohexsyl]-N'-(2,3,4,6-tetra-O-acetyl-β-D-glucose)urea 
• 1427269-54-2 N-[(1S,2S)-2-(diphenylphosphino)cyclohexsyl]-N'-(2,3,6,2',3',4',6'-hexa-O-acetyl-β-D-cellobiose)urea 

Relevant articles and documents

Cooperative, highly enantioselective phosphinothiourea catalysis of imine - Allene [3 + 2] cycloadditions

A new family of phosphinthiourea catalysts was developed for the highly enantioselective synthesis of 2-aryl-2,5-hydropyrroles via a [3 + 2] cycloaddition of an electron-deficient allene with aryl and heteroaryl diphenylphosphinoylimines. The presence of

Design and development of cyclohexane-based P,N-ligands for transition metal catalysis

(Matrix presented) R1 = H, Pht R2 = Ph, Cy A new class of cyclohexane-based P,N-ligands is readily obtained through aziridine ring opening with suitable phosphorus nucleophiles under acidic conditions. tran-1-Amino-2-diphenylphosphin