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N-(3-bromophenyl)cyclohexanecarboxamide is a chemical compound characterized by the molecular formula C13H15BrNO. It is an amide derivative of cyclohexanecarboxylic acid, featuring a 3-bromophenyl group attached to the amide nitrogen. N-(3-bromophenyl)cyclohexanecarboxamide plays a significant role in organic synthesis and medicinal chemistry due to its structural properties and potential applications.

452365-99-0

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452365-99-0 Usage

Uses

Used in Organic Synthesis:
N-(3-bromophenyl)cyclohexanecarboxamide is utilized as a building block in the synthesis of various pharmaceutical compounds and agrochemicals. Its unique structure allows for the creation of a wide range of molecules with different biological activities.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, N-(3-bromophenyl)cyclohexanecarboxamide is employed as a key intermediate for the development of new drugs. Its potential biological activity makes it a valuable candidate for research and drug discovery processes.
Used in Pharmaceutical Industry:
N-(3-bromophenyl)cyclohexanecarboxamide is used as a precursor in the production of pharmaceuticals. Its versatility in chemical reactions enables the synthesis of diverse drug molecules with therapeutic potential.
Used in Agrochemical Industry:
Similarly, in the agrochemical industry, N-(3-bromophenyl)cyclohexanecarboxamide serves as a starting material for the synthesis of various agrochemicals, such as pesticides and herbicides, contributing to the development of effective solutions for agricultural challenges.
Overall, N-(3-bromophenyl)cyclohexanecarboxamide's diverse applications in the chemical and pharmaceutical industries highlight its importance as a versatile compound with significant potential in the development of new molecules for various purposes.

Check Digit Verification of cas no

The CAS Registry Mumber 452365-99-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,5,2,3,6 and 5 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 452365-99:
(8*4)+(7*5)+(6*2)+(5*3)+(4*6)+(3*5)+(2*9)+(1*9)=160
160 % 10 = 0
So 452365-99-0 is a valid CAS Registry Number.

452365-99-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name N-(3-bromophenyl)cyclohexanecarboxamide

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:452365-99-0 SDS

452365-99-0Downstream Products

452365-99-0Relevant articles and documents

FARNESOID X RECEPTOR AGONISTS AND USES THEREOF

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Paragraph 00398, (2017/04/11)

Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.

FARNESOID X RECEPTOR AGONISTS AND USES THEREOF

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Paragraph 00394, (2017/04/11)

Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.

COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS

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Page/Page column 172, (2010/05/13)

Provided are compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.

NON-STEROIDAL FXR AGONISTS

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Page 9-11; 33; 34; Sheet 12; Sheet 15, (2010/02/07)

ABSTRACT Potent non-steroidal farnesoid X receptor (FXR) agonists are N-aryl-N-arylmethyl amido and ureido compounds having the chemical structure represented by the following formula (I): INSERT FORMULA wherein E1 is (C1-C8)alkyl, cyclohexyl, 2-furyl, 3-

Discovery and optimization of non-steroidal FXR agonists from natural product-like libraries.

Nicolaou,Evans, Ronald M,Roecker,Hughes, Robert,Downes, Michael,Pfefferkorn, Jeffery A

, p. 908 - 920 (2007/10/03)

The efficient regulation of cholesterol biosynthesis, metabolism, acquisition, and transport is an essential component of lipid homeostasis. The farnesoid X receptor (FXR) is a transcriptional sensor for bile acids, the primary product of cholesterol metabolism. Accordingly, the development of potent, selective, small molecule agonists, partial agonists, and antagonists of FXR would be an important step in further deconvoluting FXR physiology. Herein, we describe the development of four novel classes of potent FXR activators originating from natural product-like libraries. Initial screening of a 10,000-membered, diversity-orientated library of benzopyran containing small molecules for FXR activation utilizing a cell-based reporter assay led to the identification of several lead compounds possessing low micromolar activity (EC50's = 5-10 microM). These compounds were systematically optimized employing parallel solution-phase synthesis and solid-phase synthesis to provide four classes of compounds that potently activate FXR. Two series of compounds, bearing stilbene or biaryl moieties, contain members that are the most potent FXR agonists reported to date in cell-based assays. These compounds may find future utility as chemical tools in studies aimed at further defining the physiological role of FXR and discovering potential therapeutic agents for the treatment of diseases linked to cholesterol and bile acid metabolism and homeostasis.

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