592524-75-9

Usage

Uses

Used in Pharmaceutical Industry:
(E)-tert-butyl 3-(4-((N-(3-((E)-3-methoxy-3-oxoprop-1-enyl)phenyl)cyclohexanecarboxamido)methyl)phenyl)acrylate is used as a pharmaceutical intermediate for the synthesis of various medicinal compounds. Its unique structure and functional groups may enable the development of new drugs with specific therapeutic properties.
Used in Materials Science:
In the field of materials science, (E)-tert-butyl 3-(4-((N-(3-((E)-3-methoxy-3-oxoprop-1-enyl)phenyl)cyclohexanecarboxamido)methyl)phenyl)acrylate is used as a component in the development of advanced materials with tailored properties. Its reactive groups can be utilized to create new polymers, coatings, or composites with improved characteristics.
Used in Organic Synthesis:
(E)-tert-butyl 3-(4-((N-(3-((E)-3-methoxy-3-oxoprop-1-enyl)phenyl)cyclohexanecarboxamido)methyl)phenyl)acrylate serves as a key building block in organic synthesis, allowing chemists to construct more complex molecules with specific functions. Its versatility in reacting with other compounds makes it a valuable tool in the synthesis of natural products, pharmaceuticals, and other specialty chemicals.
Due to the complex and potentially reactive nature of (E)-tert-butyl 3-(4-((N-(3-((E)-3-methoxy-3-oxoprop-1-enyl)phenyl)cyclohexanecarboxamido)methyl)phenyl)acrylate, it is essential to handle it with care and conduct thorough research to fully understand its behavior and characteristics in various applications.

Upstream product

• 1663-39-4 tert-Butyl acrylate 
• 1055899-25-6 (E)-3-{3-[4-((E)-2-tert-Butoxycarbonyl-vinyl)-benzylamino]-phenyl}-acrylic acid methyl ester 
• 2719-27-9 cyclohexanylcarbonyl chloride 
• 452365-99-0 N-(3-bromophenyl)cyclohexanecarboxamide 
• 591-19-5 m-Bromoaniline 
• 208036-26-4 (E)-t-butyl 4-formylcinnamate 
• 1122-91-4 4-bromo-benzaldehyde 
• 1055899-23-4 3-{4-[(3-bromo-phenylamino)-methyl]-phenyl}-acrylic acid tert-butyl ester 
• 1055899-24-5 3-(4-{[(3-bromo-phenyl)-cyclohexanecarbonyl-amino]-methyl}-phenyl)-acrylic acid tert-butyl ester 
• 292638-85-8 acrylic acid methyl ester 

Relevant academic research and scientific papers

NON-STEROIDAL FXR AGONISTS

ABSTRACT Potent non-steroidal farnesoid X receptor (FXR) agonists are N-aryl-N-arylmethyl amido and ureido compounds having the chemical structure represented by the following formula (I): INSERT FORMULA wherein E1 is (C1-C8)alkyl, cyclohexyl, 2-furyl, 3-

Discovery and optimization of non-steroidal FXR agonists from natural product-like libraries.

The efficient regulation of cholesterol biosynthesis, metabolism, acquisition, and transport is an essential component of lipid homeostasis. The farnesoid X receptor (FXR) is a transcriptional sensor for bile acids, the primary product of cholesterol metabolism. Accordingly, the development of potent, selective, small molecule agonists, partial agonists, and antagonists of FXR would be an important step in further deconvoluting FXR physiology. Herein, we describe the development of four novel classes of potent FXR activators originating from natural product-like libraries. Initial screening of a 10,000-membered, diversity-orientated library of benzopyran containing small molecules for FXR activation utilizing a cell-based reporter assay led to the identification of several lead compounds possessing low micromolar activity (EC50's = 5-10 microM). These compounds were systematically optimized employing parallel solution-phase synthesis and solid-phase synthesis to provide four classes of compounds that potently activate FXR. Two series of compounds, bearing stilbene or biaryl moieties, contain members that are the most potent FXR agonists reported to date in cell-based assays. These compounds may find future utility as chemical tools in studies aimed at further defining the physiological role of FXR and discovering potential therapeutic agents for the treatment of diseases linked to cholesterol and bile acid metabolism and homeostasis.