453524-57-7

Basic information

• Product Name: ETHYL 2-(4-(PHENYLAMINO)-3,5-THIAZOLYL)ACETATE
• Synonyms: ETHYL 2-(4-(PHENYLAMINO)-3,5-THIAZOLYL)ACETATE
• CAS NO: 453524-57-7
• Molecular Formula: C₁₃H₁₄N₂O₂S
• Molecular Weight: 262.33
• Mol File: 453524-57-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ETHYL 2-(4-(PHENYLAMINO)-3,5-THIAZOLYL)ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2-(4-(PHENYLAMINO)-3,5-THIAZOLYL)ACETATE(453524-57-7)
• EPA Substance Registry System: ETHYL 2-(4-(PHENYLAMINO)-3,5-THIAZOLYL)ACETATE(453524-57-7)

Safety Data

• Hazardous Substances Data: 453524-57-7(Hazardous Substances Data)

Upstream product

• 18418-42-3 phenyl-dithiocarbamic acid; sodium salt 
• 1074-52-8 ammonium phenyldithiocarbamate 
• 51034-34-5 potassium aniline dithiocarbamate 
• 1226922-89-9 C₅H₅N*C₇H₇NS₂ 
• 141-97-9 ethyl acetoacetate 
• 103-85-5 monophenylthiourea 
• 43009-16-1 phenyldithiocarbamic acid triethylamine salt 
• 13176-46-0 4-bromoethyl acetoacetate 

Downstream Products

• 33856-02-9 3?(2?(phenylamino)thiazol?4?yl)?2H?chromen?2?one 

Relevant articles and documents

CuBr2 mediated synthesis of 2-Aminothiazoles from dithiocarbamic acid salts and ketones

In a one-pot procedure, CuBr2 has been used as a efficient desulfurizing agent in the synthesis of 2-aminothiazoles by the condensation of in situ-generated 1-substituted thioureas from their dithiocarbamic acid salts, with in situ-generated α-bromoketones from ketones. All reactions were carried out under optimized reaction conditions and gave the target products in 61–95% yield.

Bromineless bromine as an efficient desulfurizing agent for the preparation of cyanamides and 2-aminothiazoles from dithiocarbamate salts

In a one-pot procedure, bromineless brominating reagent 1,1'-(ethane-1,2-diyl)dipyridinium bistribromide (EDPBT) has been used as a desulfurizing agent in the preparation of organic cyanamides and substituted thiazoles starting from dithiocarbamic acid salts. In this approach, alkyl/aryl isothiocyantes were first obtained by the desulfurization of dithiocarbamic acid salts with EDPBT. The in situ-generated isothiocyanates reacts with an aqueous ammonia, forming alkyl or aryl thioureas, which on subsequent oxidative desulfurization with EDPBT led to the formation of corresponding cyanamides in good yields. Alternatively, an efficient one-pot synthesis of substituted thiazoles has been achieved by the condensation of the in situ-generated 1-aryl thioureas with the in situ-generated -bromoketones from ketones, again using EDPBT. The reagent EDPBT can be easily prepared from the readily available reagents. Desulfurizing ability dominates over its brominating ability for substrates amenable to bromination.