460720-86-9Relevant articles and documents
Zn(OAc)2·2H2O-catalyzed one-pot efficient synthesis of α-amino nitriles
Reddy, V. Venkata Rami,Saritha,Ramu,Varala, Ravi,Jayashree
, p. 7439 - 7442 (2015/04/22)
A mild, efficient one-pot three component strecker reaction involving electronically and structurally divergent aldehydes, amines and trimethly silyl cyanide in chloroform as solvent at room temperature was accomplished in moderate to excellent yields using an inexpensive and readily available catalyst, Zn(OAc)2.2H2O.
Discovery and biological evaluation of adamantyl amide 11β-HSD1 inhibitors
Webster, Scott P.,Ward, Peter,Binnie, Margaret,Craigie, Eilidh,McConnell, Kirsty M.M.,Sooy, Karen,Vinter, Andy,Seckl, Jonathan R.,Walker, Brian R.
, p. 2838 - 2843 (2008/02/05)
A series of adamantyl amide 11β-HSD1 inhibitors has been discovered and chemically modified. Selected compounds are selective for 11β-HSD1 over 11β-HSD2 and possess excellent cellular potency in human and murine 11β-HSD1 assays. Good pharmacodynamic characteristics are observed in ex vivo assays.
N-α-cyano derivatives of some N-benzyl azacycloalkanes
Petride, Horia,Corbu, Andreea,Florea, Cristina,Petride, Aurica,Udrea, Silvia
, p. 635 - 642 (2007/10/03)
Endocyclic (1) and exocyclic (2) (i.e., CN at the aliphatic ring-carbon and in the benzylic position, respectively) N-α-cyano derivatives of N-benzylmorpholine, -piperidine, -pyrrolidine, -piperazine, and N,N'-dibenzylpiperazine were prepared and their s
