- A dimethacrylate cross-linker cleavable under thermolysis or alkaline hydrolysis conditions: Synthesis, polymerization, and degradation
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We develop a new platform based on 2,6-pyridinediethanol diesters for introducing polymer degradability under thermolysis or alkaline hydrolysis conditions, with the latter being rare in polymers. Such labile diesters can be cross-linkers, bifunctional initiators and inimers. We demonstrate the power of this platform through the synthesis of the 2,6-pyridinediethanol dimethacrylate cross-linker, its controlled (co)polymerization, and the thermal and hydrolytic cleavage of its (co)polymers.
- Elladiou, Marios,Patrickios, Costas S.
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supporting information
p. 3135 - 3138
(2016/02/23)
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- Cycloalkyl-dione Derivatives And Methods Of Their Use
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The present invention is directed to compounds of formula I: wherein A is n is 0, 1, or 2; m is 0 or 1; R1 is H or C1-6alkyl and R2 is H, C1-6 alkyl, substituted or unsubstituted aryl, or substituted or unsubsti
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Page/Page column 23
(2013/02/28)
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- Compounds - 801
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Spirocyclic amide derivatives of formula I wherein ArCH2CH2NH— represents a β-adrenoceptor binding group, processes for their preparation, pharmaceutical compositions containing them, a process for preparing such pharmaceutical compo
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Page/Page column 78
(2011/04/14)
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- Cyclopentane-1,3-dione: A novel isostere for the carboxylic acid functional group. Application to the design of potent thromboxane (A2) receptor antagonists
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Cyclopentane-1,3-diones are known to exhibit pKa values typically in the range of carboxylic acids. To explore the potential of the cyclopentane-1,3-dione unit as a carboxylic acid isostere, the physical-chemical properties of representative co
- Ballatore, Carlo,Soper, James H.,Piscitelli, Francesco,James, Michael,Huang, Longchuan,Atasoylu, Onur,Huryn, Donna M.,Trojanowski, John Q.,Lee, Virginia M.-Y.,Brunden, Kurt R.,Smith, Amos B.
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experimental part
p. 6969 - 6983
(2011/12/02)
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- Diphenylmethyl compounds useful as muscarinic receptor antagonists
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This invention provides compounds of formula I: wherein a, b, c, e, m, n, Ar1, R1, R2, R3, R4a, R4b, R5 and R6 are as defined in the specification. The compounds of fo
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Page/Page column 19
(2008/06/13)
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- Synthesis and inhibitory effects op bivalent sialyl Lewis X analogs at preventing cell adhesion
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Several sialyl Lewis X (SLeX) dimers attached to symmetric linkers, 1,3-di(ω-hydroxyalkyl)-benzene, 1,3-di(ω-hydroxyalkoxy)benzene, and 1,3-di(ω-hydroxyalkoxy)cyclohexane, were synthesized and evaluated for their inhibitory activity against adhesion of HL
- Miyauchi, Hiroshi,Yuri, Masatoshi,Tanaka, Masashi,Kawamura, Nobuko,Hayashi, Masaji
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p. 989 - 992
(2007/10/03)
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- A New General Synthesis of Polycyclic Aromatic Compounds Based on Enamine Chemistry
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Alkylation of enamines and enamine salts by benzylic and (β-haloethyl)aryl halides, respectively, followed by acidic cyclodehydration and dehydrogenation provides an efficient synthetic approach to a wide range of polycyclic aromatic compounds of diverse structural types.Specific polycyclic hydrocarbons synthesized by this route include benzo- and benzofluorene, 7H-dibenzo-, 13H-dibenzo-, and 13H-dibenzofluorene, 15H-tribenzofluorene, dibenzochrysene, benzopentaphene, indenofluorene, fluorenofluorene, octahydrodibenzanthracene, dibenzanthracene, octahydrodibenzanthracene, dibenzanthracene, picene, benzopicene, 1H-benzaceanthrylene, and 4H-cyclopentachrysene.This method with appropriate modifications appears to be potentially broader in scope than established traditional methods of polycyclic hydrocarbon synthesis.
- Harvey, Ronald G.,Pataki, John,Cortez, Cecilia,Raddo, Pasquale Di,Yang, ChengXi
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p. 1210 - 1217
(2007/10/02)
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