462068-88-8

Basic information

• Product Name: 1-benzyl-2-(4-methoxyphenyl)-5-oxo-3-pyrrolidinecarboxylic acid
• Synonyms: 1-benzyl-2-(4-methoxyphenyl)-5-oxo-3-pyrrolidinecarboxylic acid
• CAS NO: 462068-88-8
• Molecular Formula: C19H19NO4
• Molecular Weight: 325.36
• Mol File: 462068-88-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-benzyl-2-(4-methoxyphenyl)-5-oxo-3-pyrrolidinecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-2-(4-methoxyphenyl)-5-oxo-3-pyrrolidinecarboxylic acid(462068-88-8)
• EPA Substance Registry System: 1-benzyl-2-(4-methoxyphenyl)-5-oxo-3-pyrrolidinecarboxylic acid(462068-88-8)

Safety Data

• Hazardous Substances Data: 462068-88-8(Hazardous Substances Data)

Usage

Chemical structure

1-benzyl-2-(4-methoxyphenyl)-5-oxo-3-pyrrolidinecarboxylic acid is a chemical compound with a benzyl group, a 4-methoxyphenyl group, and a pyrrolidinecarboxylic acid group.

Physical appearance

It is a white to off-white powder.

Solubility

The compound is soluble in organic solvents.

Application

It is commonly used as a building block in organic synthesis and pharmaceutical development.

Medicinal properties

The compound has potential medicinal properties, particularly in the treatment of various diseases and disorders.

Versatility

Its unique structure and functional groups make it a versatile and valuable chemical for research and development in the field of drug discovery and synthesis.

Upstream product

• 110-15-6 succinic acid 
• 622-72-0 N-(4-methoxylbenzylidene)benzylamine 
• 108-30-5 succinic acid anhydride 
• 130517-94-1 (E)-N-benzyl-1-(4-methoxyphenyl)methanimine 
• 77220-06-5 2,5-bis<(trimethylsilyl)oxy>furan 

Relevant articles and documents

Highly diastereoselective synthesis of β-carboxy-γ-lactams and their ethyl esters via Sc(OTf)3-catalyzed imino Mukaiyama-aldol type reaction of 2,5-bis(trimethylsilyloxy)furan with imines

(Chemical Equation Presented) Functionalized γ-lactams are found to be crucial intermediates in the synthesis of biologically important natural products. We herein described a highly diastereoselective synthesis of β-carboxy-γ-lactams and their ethyl este

1,1′-Carbonyldiimidazole as a cyclodehydrating agent for the Castagnoli–Cushman reaction of dicarboxylic acids and imines

A novel protocol for the Castagnoli–Cushman reaction of dicarboxylic acids and imines comprises the use of 1,1′-carbonyldiimidazole as the cyclodehydrating agent to in situ produce the intermediate anhydrides. In contrast to previously developed procedure

The rare: Cis -configured trisubstituted lactam products obtained by the Castagnoli-Cushman reaction in N, N -dimethylformamide

Unlike its trans counterpart, the cis-configured scaffold derived from the Castagnoli-Cushman reaction (CCR) is scarce and has not been explored in bioactive compound design. We found that conducting this reaction in DMF (in contrast to conventional toluene or xylene) led to a significantly higher proportion of cis-configured lactams in the diastereomeric product mixture. This allowed us, for the first time, to obtain and thoroughly characterize both stereoisomers of a significant number of lead-like CCR lactams. Simple rules for 1H NMR-based stereochemical assignment have been devised and correlated with the single-crystal X-ray structures obtained for pure cis- and trans-configured lactams.