4668-43-3

Upstream product

• 4515-23-5 N-benzyloxycarbonyl-L-aspartic acid anhydride 
• 64-17-5 ethanol 
• 4515-21-3 N-benzyloxycarbonylaspartic acid 
• 78553-59-0 ethyl (S)-2-(benzyloxycarbonylamino)-4-oxobutanoate 
• 1152-61-0 N-Cbz-L-Asp 
• 88966-25-0 N-benzyloxycarbonyl-L-aspartic anhydride 

Downstream Products

• 23632-73-7 N-carbobenzoxy-L-aspartic acid amide 
• 36702-55-3 (S)-2-Benzyloxycarbonylamino-succinic acid 4-tert-butyl ester 1-ethyl ester 
• 80977-08-8 O-(2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl)-(1<*>6)-O-(2,3,4-tri-O-acetyl-β-D-glucopyranosyl)-(1<*>6)-2,3,4-tri-O-acetyl-N-(O-ethyl-N-benzyloxycarbonyl-L-β-aspartyl)-α-D-glucopyranosylamine 
• 76051-36-0 2,3,4,6-tetra-O-acetyl-N-(α-ethyl benzyloxycarbonyl-L-aspartyl)-α-D-glucopyranosylamine 
• 80977-08-8 O-(2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl)-(1<*>6)-O-(2,3,4-tri-O-acel-β-D-glucopyranosyl)-(1<*>6)-(2,3,4-tri-O-acetyl-N-)O-ethyl-N-(O-ethyl-N-benzyloxycarbonyl-L-β-aspartyl)-β-D-glucopyranosylamine 
• 849411-39-8 ethyl (S)-2-(benzyloxycarbonylamino)-4-hydroxybutanoate 
• 719307-97-8 (2S)-2-benzyloxycarbonylamino-N-[2-(4-chloro-phenyl)-2-oxo-ethyl]-succinamic acid ethyl ester 
• 719307-93-4 (2S)-2-benzyloxycarbonylamino-N-(1-methyl-2-oxo-2-phenyl-ethyl)-succinamic acid ethyl ester 
• 872221-56-2 potassium-(2S)-2-{1-[(1S)-1-isobutoxycarbonyl-2-(5-phenyl-oxazol-2-yl)-ethylcarbamoyl]-cyclopentylmethyl}4-methoxy-butyrate 
• 719308-47-1 (2S)-2-amino-3-(5-phenyl-oxazol-2-yl)-propionic acid isobutyl ester hydrochloride 
• 719308-31-3 (2S)-2-amino-3-(5-phenyl-oxazol-2-yl)-propionic acid ethyl ester hydrochloride 
• 719307-95-6 (2S)-2-benzyloxycarbonylamino-N-(2-oxo-2-phenyl-ethyl)-succinamic acid ethyl ester 
• 719307-48-9 (2S)-2-{1-[(1S)-1-isobutoxycarbonyl-2-(5-phenyl-oxazol-2-yl)-ethylcarbamoyl]-cyclopentylmethyl}4-methoxy-butyric acid 
• 719307-47-8 C₂₆H₃₃ClN₂O₇ 

Relevant academic research and scientific papers

TLR2 MODULATOR COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

The present disclosure relates to compounds which modulate the activity of Toll-like receptor (TLR) proteins, including agonists or activators, partial agonists, and antagonists. Of particular interest of compounds that modulate the activity of TLR2, as well as methods of using such compounds to treat cancer and other disorders associated with a TLR2 pathway.

Aminocatalytic enantioselective anti-mannich reaction of aldehydes with in situ generated N-cbz and N-boc imines

(Chemical Equation Presented) The title reaction catalyzed by the commercially available chiral secondary amine 1 proceeds with high stereocontrol and allows the in situ generation of N-carbamate-protected imines from stable a-amido sulfones 2. This organocatalytic approach provides easy and convenient access to valuable compounds 3 in high yield, with very good anti selectivity,and in high enantiomeric purity.

NEUTRAL ENDOPEPTIDASE INHIBITOR POLYMORPH

Disclosed are (2S)-2-{1-[(1S)-1-Isobutoxycarbonyl-2-(5-phenyl-oxazol-2-yl)-ethylcarbamoyl]-cyclopentylmethyl}-4-methoxy-butyric, Potassium-(2S)-2-{1-[(1S)-1-Isobutoxycarbonyl-2-(5-phenyl-oxazol-2-yl)-ethylcarbamoyl]-cyclopentylmethyl}-4-methoxy-butyrate,

A flexible approach to (S)-3-amino-2-pyrrolidinone derivatives

Starting from (S)-aspartic acid, a flexible chemoselective approach to (S)-3-amino-2-pyrrolidinone derivatives was reported. The (S)-3-amino-2-pyrrolidinone derivatives thus synthesized are useful templates for designing medicinal interesting compounds.

PAPAIN-ASSISTED RESOLUTION OF NATURAL AND XENOBIOTIC α-AMINO ACIDS

A new and convenient method for the preparation of pure enantiomers of α-amino acids is described.Industrial papain, catalyzes the synthesis of L-Z-amino acid ethyl esters in ethanolic medium, with good yields.These esters are obtained from DL-Z-amino acids with 100percent optical purity.Unreactive D-Z-amino acids are readily isolated from reaction medium.Physical constants of natural and xenobiotic L-Z-amino acid esters and D-Z-amino acids are described.