474-69-1Relevant articles and documents
Vitamin D1
Tan,Tham,Okamura
, p. 2345 - 2346 (2000)
The X-ray crystallographic structure of vitamin D1 reveals a sandwich-like 1:1 heterodimeric complex of lumisterol2 and vitamin D2 with the latter in its α-chair conformer.
Methods for preparing cholesterol, and derivatives and analogs thereof
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Paragraph 0394-0395; 0406-008, (2021/04/07)
The present invention relates to the field of pharmaceutical chemistry, and in particular to methods of preparing cholesterol,and derivatives and analogs thereof. The cholesterol derivatives include, but not limited to, 7-dehydrocholesterol, 25-hydroxycholesterol, 25- hydroxy7dehydrocholesterol and ergosterol. In the invention, phytosterol can be used as a raw material to prepare the compound shown in the formula I through microbial conversion, and then cholesterol and the derivatives and analogues thereof are prepared.
PRODUCTION AND PROPERTIES OF 1,4-CYCLIC ADDUCTS OF STEROID 5,7-DIENES WITH 3,6-PYRIDAZINEDIONE AND 1,4-PHTHALAZINEDIONE
Bogoslovskii, N. A.,Litvinova, G. E.,Titova, I. A.,Samokhvalov, G. I.,Mairanovskii, V. G.,et al.
, p. 1705 - 1710 (2007/10/02)
1,3-Phthalazinedione and 3,6-pyridazinedione, obtained by the action of lead tetraacetate or manganese dioxide on phthalohydrazide and of lead tetraacetate on malehydrazide, form 1,4-cyclic adducts in reaction with steroid 5,7-dienes; the reaction is promoted by the presence of aliphatic alcohols.The initial dienes can be regenerated from the synthesized cyclic adducts by reductive cleavage with complex metal hydrides or by electrochemical reduction.In addition to ergosterol, the action of a water-alcohol solution of alkali on the cyclic adduct of ergosterol with 1,4-phthalazinedione gives a salt-like compound, which is converted into 9(11)-dehydroergosterol and phthalohydrazide by the action of acids.
