476621-08-6

Basic information

• Product Name: Furo[3,2-c]quinoline, 5-ethyl-2,3,3a,4,5,9b-hexahydro-, (3aR,9bR)-rel- (9CI)
• Synonyms: Furo[3,2-c]quinoline, 5-ethyl-2,3,3a,4,5,9b-hexahydro-, (3aR,9bR)-rel- (9CI)
• CAS NO: 476621-08-6
• Molecular Formula: C13H17NO
• Molecular Weight: 203.28018
• Product Categories: ETHYL
• Mol File: 476621-08-6.mol

Chemical Properties

• Boiling Point: 310.7±35.0 °C(Predicted)
• Appearance: /
• Density: 1.068±0.06 g/cm3(Predicted)
• PKA: 5.36±0.20(Predicted)
• CAS DataBase Reference: Furo[3,2-c]quinoline, 5-ethyl-2,3,3a,4,5,9b-hexahydro-, (3aR,9bR)-rel- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Furo[3,2-c]quinoline, 5-ethyl-2,3,3a,4,5,9b-hexahydro-, (3aR,9bR)-rel- (9CI)(476621-08-6)
• EPA Substance Registry System: Furo[3,2-c]quinoline, 5-ethyl-2,3,3a,4,5,9b-hexahydro-, (3aR,9bR)-rel- (9CI)(476621-08-6)

Safety Data

• Hazardous Substances Data: 476621-08-6(Hazardous Substances Data)

Upstream product

• 1191-99-7 2,3-dihydro-2H-furan 
• 62992-36-3 Ethoxymethyl-ethyl-phenyl-amine 
• 109-99-9 tetrahydrofuran 
• 613-97-8 N-methyl-N-ethylaniline 

Relevant articles and documents

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Cu-catalyzed oxidative Povarov reactions between N,N-dialkylanilines and saturated oxa- or thiacycles with tert-butyl hydroperoxide (TBHP) are described; notably, the reactions use neither [4π] nor [2π]-motifs as the initial reagents. The use of cheap alkane-based substances as building units is of mechanistic and practical interest as two inert sp3 C-H bonds are activated.

Stereoselective approach to the pyrroloquinoline core of martinelline

The synthesis of α-aminonitrile 4, a potent precursor to the martinellines is described. The preparation of the pyrroloquinoline core was realized in one step (90% yield) using a formal [4π+2π] cyclocondensation involving the cationic aza-diene 6 and the 1-(benzyloxy)carbonyl-2-pyrroline 5 as dienophile. The stereo-chemical outcome of the cyanation procedure performed on the tricyclic core thus obtained is discussed.