482308-06-5Relevant articles and documents
COMPOUNDS AND THEIR USES AS SPLEEN TYROSINE KINASE INHIBITORS
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Paragraph 0085, (2021/12/28)
Provided are compounds of Formula (I) which can be used as Syk inhibitors and potently as therapeutic agents against diseases mediated by Syk.
QUINOLINE AND QUINAZOLINE COMPOUNDS AND METHODS OF USE THEREOF
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Paragraph 00338-00339, (2020/10/09)
Compounds and methods for their preparation and use as therapeutic or prophylactic agents, fo example for treatment of cancer, bacterial or viral diseases by targeting Ectonucleotide Pyrophosphatase/Phosphodiesterase- 1 (ENPP1).
A class of FLT3 kinase inhibitors, preparation and application thereof
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Paragraph 0234; 0241-0243, (2020/06/20)
The invention relates to a class of FLT3 kinase inhibitors, preparation and application thereof, wherein specifically the compound has a structure represented by a formula (I), and all groups and substituents are defined in the specification. The invention also discloses a preparation method of the compound, and application of the compound in inhibition of FLT3.
VEGFR TYROSINE KINASE INHIBITORS
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Page/Page column 32, (2014/12/12)
Novel compounds, their prodrugs, and the pharmaceutically acceptable salts as pharmaceutical compositions containing such compounds useful in treating certain diseases modulated by the inhibition of vascular endothelial growth factors (VEGFs) receptor tyrosine kinases are provided. In particular, compounds and compositions and the methods for the prophylaxis, management and treatment of cancers through the inhibition of VEGF receptor tyrosine kinases are provided.
PYRROLONE OR PYRROLIDINONE MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS
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Paragraph 00207, (2014/03/26)
The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are melanin concentrating hormone receptor-1 (MCHR1) antagonists which may be used as medicaments.
IMIDAZOPYRAZINE SYK INHIBITORS
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Paragraph 0220, (2014/01/08)
Certain imidazopyrazines and pharmaceutical compositions thereof are provided herein. Methods of treating patients suf-fering from certain diseases and disorders responsive to the inhibition of Syk activity, which comprises administering to such patients an amount of an imidazopyrazine compound effective to reduce signs or symptoms of the disease or dis-order are provided.
Discovery of 2,4-bis-arylamino-1,3-pyrimidines as insulin-like growth factor-1 receptor (IGF-1R) inhibitors
Buchanan, John L.,Newcomb, John R.,Carney, David P.,Chaffee, Stuart C.,Chai, Lilly,Cupples, Rod,Epstein, Linda F.,Gallant, Paul,Gu, Yan,Harmange, Jean-Christophe,Hodge, Kathy,Houk, Brett E.,Huang, Xin,Jona, Janan,Joseph, Smriti,Jun, H. Toni,Kumar, Rakesh,Li, Chun,Lu, John,Menges, Tom,Morrison, Michael J.,Novak, Perry M.,Van Der Plas, Simon,Radinsky, Robert,Rose, Paul E.,Sawant, Satin,Sun, Ji-Rong,Surapaneni, Sekhar,Turci, Susan M.,Xu, Keyang,Yanez, Evelyn,Zhao, Huilin,Zhu, Xiaotian
scheme or table, p. 2394 - 2399 (2011/05/15)
The insulin-like growth factor-1 receptor (IGF-1R) plays an important role in the regulation of cell growth and differentiation, and in protection from apoptosis. IGF-1R has been shown to be an appealing target for the treatment of human cancer. Herein, w
COMBINATION THERAPY OF SUBSTITUTED OXAZOLIDINONES
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, (2010/06/11)
The present invention relates to combinations of A) oxazolidinones of the formula (I) with B) acetylsalicylic acid (aspirin) and C) an ADP receptor antagonist, in particular P2Y12 purinoreceptor blocker, to a process for producing these combinations and to the use thereof as medicaments, in particular for the prophylaxis and/or treatment of thromboembolic disorders.
MICROANGIOPATHY TREATMENT AND PREVENTION
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, (2010/07/04)
The present invention relates to the use of selective factor Xa inhibitors, in particular of oxazolidinones of the formula (I) for the treatment and/or prophylaxis of microangiopathies and also their use for the production of medicaments for the treatment and/or prophylaxis of microangiopathies.
Combination Therapy Comprising Substituted Oxazolidinones for the Prevention and Treatment of Cerebral Circulatory Disorders
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, (2009/01/20)
The present invention relates to combinations of A) oxazolidinones of the formula (I), with B) antiarrhythmics, processes for the production of these combinations, their use for the prophylaxis and/or treatment of diseases, and their use for the manufacture of medicaments for the prophylaxis and/or treatment of diseases, especially of thromboembolic disorders and/or complications.