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485-91-6

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Compounds and compositions for treating infection
Compounds from 14 Kenyan plants, including from the root of Dovyalis abyssinica and Clutia robusta have been characterized and isolated, and their uses are disclosed.
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(2009/04/24)

From berbines to protopines: Regiocontrolled Hofmann elimination/ hydroboration/oxidation of N-substituted berbinium salts
An improved synthetic approach to protopines based on the sequential Hofmann elimination, hydroboration and oxidation of N-(arylmethyl)berbinium salts has been designed. By using berberine chloride as the starting material, this sequence of reactions has provided two new nonnatural protopines, N-benzyl-N-nordihydroallocriptopine and N-(p-methoxybenzyl)-N- nordihydroallocriptopine and the natural allocriptopine. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.
Valpuesta, Maria,Diaz, Amelia,Suau, Rafael,Torres, Gregorio
p. 964 - 971
(2007/10/03)

Simple synthesis of the protopine alkaloids muramine and allocryptopine from tetrahydroprotoberberine derivatives
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Ronsch
p. 64 - 65
(2007/10/02)

ENZYMATIC FORMATION OF PROTOPINES BY A MICROSOMAL CYTOCHROME P-450 SYSTEM OF CORYDALIS VAGINANS
A microsomal cytochrome P-450-NADPH dependent enzyme which hydroxylates stereo- and regiospecifically carbon atom 14 of (S)-cis-N-methyltetrahydroprotoberberines has been discovered in a number of plant cell cultures originating from species containing protopine alkaloids; the monooxygenase was solubilized, partially purified (100-fold) and characterized.
Rueffer, M.,Zenk, M. H.
p. 5307 - 5310
(2007/10/02)

Biosynthesis of benzo[c]phenanthridine alkaloids sanguinarine, chelirubine and macarpine
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Takao,Kamigauchi,Okada
p. 473 - 484
(2007/10/02)

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2086-83-1
berberine

Chemical Properties

Melting Point: 160～161℃
Boiling Point: 552.7°Cat760mmHg
Flash Point:288.1°C
Density: 1.216g/cm³
Solubility:DMSO (Slightly, Heated), Methanol (Slightly)
Storage Temp.:-20°C Freezer
Vapor Pressure: 2.92E-12mmHg at 25°C
PKA: 7.86±0.20(Predicted)
PSA: 57.23000
LogP: 2.78370

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