485828-46-4

Basic information

• Product Name: 1-(2-Pyridinyl)-cyclobutanecarbonitrile
• Synonyms: 1-(2-Pyridinyl)-cyclobutanecarbonitrile;Cyclobutanecarbonitrile, 1-(2-pyridinyl)-
• CAS NO: 485828-46-4
• Molecular Formula: C10H10N2
• Molecular Weight: 158.1998
• Mol File: 485828-46-4.mol

Chemical Properties

• Boiling Point: 319.924°C at 760 mmHg
• Flash Point: 114.62°C
• Appearance: /
• Density: 1.125g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.562
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(2-Pyridinyl)-cyclobutanecarbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-Pyridinyl)-cyclobutanecarbonitrile(485828-46-4)
• EPA Substance Registry System: 1-(2-Pyridinyl)-cyclobutanecarbonitrile(485828-46-4)

Safety Data

• Hazardous Substances Data: 485828-46-4(Hazardous Substances Data)

Usage

Uses

1. Used in Pharmaceutical Industry:
1-(2-Pyridinyl)-cyclobutanecarbonitrile is used as a synthetic intermediate for the development of pyrazolopyrimidine derivatives and analogs. These derivatives are known for their therapeutic potential in the treatment of autoimmune diseases, such as rheumatoid arthritis, lupus, and multiple sclerosis. 1-(2-Pyridinyl)-cyclobutanecarbonitrile's unique structure allows for the creation of new molecules with improved efficacy and reduced side effects.
2. Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 1-(2-Pyridinyl)-cyclobutanecarbonitrile serves as a valuable building block for the design and synthesis of novel bioactive molecules. Its reactivity and structural diversity make it an attractive candidate for the development of new drugs targeting various diseases, including cancer, neurological disorders, and infectious diseases.
3. Used in Drug Synthesis:
1-(2-Pyridinyl)-cyclobutanecarbonitrile is utilized as a key component in the synthesis of various pharmaceutical compounds. Its unique chemical properties enable the formation of new molecular entities with potential applications in the treatment of a wide range of medical conditions. 1-(2-Pyridinyl)-cyclobutanecarbonitrile's versatility in chemical reactions allows for the creation of diverse drug candidates with improved pharmacological profiles.

InChI:InChI=1/C10H10N2/c11-8-10(5-3-6-10)9-4-1-2-7-12-9/h1-2,4,7H,3,5-6H2

Upstream product

• 372-48-5 2-fluoropyridine 
• 4426-11-3 cyclobutanecarbonitrile 
• 2739-97-1 pyridine-2-acetonitrile 
• 109-64-8 1,3-dibromo-propane 

Relevant articles and documents

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The present invention relates to a novel compound having an activity of inhibiting histone deacetylase 6 (HDAC6), an optical isomer thereof or a pharmaceutically acceptable salt thereof, a use thereof for preparation of a drug for treatment, a pharmaceutical composition comprising the same, a treatment method using the composition, and a method for preparing the same. The novel compound, an optical isomer thereof or a pharmaceutically acceptable salt thereof according to the present invention has an activity of inhibiting histone deacetylase 6 (HDAC6), and is effective for preventing or treating HDAC6-related diseases, including infectious diseases; neoplasm; endocrine, nutritional and metabolic diseases; mental and behavior disorders; nerve disorders; eye and adnexa diseases; cardiovascular diseases; respiratory diseases; digestive organ diseases; skin and subcutaneous tissue diseases; musculoskeletal and connective tissue diseases; or congenital malformation, deformation and chromosomal abnormality.COPYRIGHT KIPO 2017

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