1-(2-Pyridinyl)-cyclobutanecarbonitrile

Base Information

• Chemical Name: 1-(2-Pyridinyl)-cyclobutanecarbonitrile
• CAS No.: 485828-46-4
• Molecular Formula: C10H10N2
• Molecular Weight: 158.20000
• Hs Code.: 2933399090
• Mol file: 485828-46-4.mol

Synonyms:1-(2-Pyridinyl)-cyclobutanecarbonitrile;1-(Pyridin-2-yl)cyclobutanecarbonitrile;

Chemical Property of 1-(2-Pyridinyl)-cyclobutanecarbonitrile

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 319.924oC at 760 mmHg
• Flash Point: 114.62oC
• PSA: 36.68000
• Density: 1.125g/cm3
• LogP: 2.02688
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

1-(2-Pyridinyl)cyclobutanecarbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-(2-Pyridinyl)cyclobutanecarbonitrile is an intermediate in the synthesis of pyrazolopyrimidine derivatives and analogs used in the treatment of autoimmune diseases.

Technology Process of 1-(2-Pyridinyl)-cyclobutanecarbonitrile

There total 3 articles about 1-(2-Pyridinyl)-cyclobutanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-fluoropyridine (372-48-5) + cyclobutanecarbonitrile (4426-11-3) → 1-(pyridin-2-yl)cyclobutanecarbonitrile (485828-46-4)

Guidance literature:

With sodium hexamethyldisilazane; In tetrahydrofuran; toluene; at 0 - 20 ℃; for 20h;

Reference yield: 11.4%

pyridine-2-acetonitrile (2739-97-1) + 1,3-dibromo-propane (109-64-8) → 1-(pyridin-2-yl)cyclobutanecarbonitrile (485828-46-4)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 18h;

Reference yield:

→ 1-(pyridin-2-yl)cyclobutanecarbonitrile (485828-46-4)

Guidance literature:

upstream raw materials:

2-fluoropyridine

cyclobutanecarbonitrile

pyridine-2-acetonitrile

1,3-dibromo-propane

Refernces

• 1、 -. "NOVEL TRPV3 MODULATORS". Paragraph 0253; 0308. . Retrieved 2013/06/27.
• 2、 -. "DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-α]IMIDAZOLE-3- CARBOXYLIC ACID AMIDES". Page/Page column 151. . Retrieved 2009/07/03.