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499220-14-3

sunitinib malate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 499220-14-3 Structure

  • Basic information

    1. Product Name: sunitinib malate
    2. Synonyms: sunitinib malate
    3. CAS NO:499220-14-3
    4. Molecular Formula:
    5. Molecular Weight: 532.569
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 499220-14-3.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: sunitinib malate(CAS DataBase Reference)
    10. NIST Chemistry Reference: sunitinib malate(499220-14-3)
    11. EPA Substance Registry System: sunitinib malate(499220-14-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 499220-14-3(Hazardous Substances Data)

499220-14-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 499220-14-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,9,9,2,2 and 0 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 499220-14:
(8*4)+(7*9)+(6*9)+(5*2)+(4*2)+(3*0)+(2*1)+(1*4)=173
173 % 10 = 3
So 499220-14-3 is a valid CAS Registry Number.

499220-14-3Relevant articles and documents

Malic acid lin's preparation method

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Paragraph 0029; 0034; 0036; 0041; 0043, (2019/06/12)

The present invention relates to a sunitinib malate preparation method, wherein particularly 2,4-dimethyl-5-aldehyde-1H-pyrrole-3-carboxylic acid is adopted as a starting raw material, carboxyl activation with carbonyl diimidazole is performed, the obtained material and N, N-diethylethylenediamine are subjected to condensation under catalysis of 1-hydroxybenzotriazole to obtain an intermediate 1, the intermediate 1 and 5-fluoro-2-oxindole react to obtain sunitinib, and the sunitinib and malic acid are directly subjected to salifying without separation so as to obtain the target product. The method of the present invention has characteristics of easy operation, high yield and high product purity, and is suitable for industrial production.

PROCESS FOR THE PREPARATION OF N-[2-DIETHYLAMINO)ETHYL]-5-[(5-FLUORO-1,2-DIHYDRO-2-OXO-3H-INDOL-3-YLIDENE)METHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE

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Page/Page column 30; 31, (2010/12/26)

The present invention relates to processes for the preparation of N-[2-(Diethylamino) ethyl]-5-[ (5-fluoro-1, 2 -dihydro-2-oxo-3H-indol-3-ylidene) methyl] -2, 4-dimethyl-I H-pyrrole- 3 -carboxamide of formula (VI).

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