342641-94-5

Basic information

• Product Name: N-(2-(Diethylamino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide
• Synonyms: 1H-PYRROLE-3-CARBOXAMIDE, N-[2-(DIETHYLAMINO)ETHYL]-5-[(5-FLUORO-1,2-DIHYDRO-2-OXO-3H-INDOL-3-YLIDENE)METHYL]-2,4-DIMETHYL-(9CI);5-(5-Fluoro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxylicacid(2-diethylamino-ethyl)-amide;1H-PYRROLE-3-CARBOXAMIDE, N-[2-(DIETHYLAMINO)ETHYL]-5-[(5-FLUORO-1,2-DIHYDRO-2-OXO-3H-INDOL-3-YLIDENE)METHYL]-2,4-DIMETHYL-;5-(5-Fluoro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxylicacid(2-diethylamino-ethyl)-am;N-(2-(Diethylamino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide;N-[2-(Diethylamino)ethyl]-5-[(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide;1-[carbaMoyl(diethylaMino)Methyl]-5-[(5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene)Methyl]-2,4-diMethyl-1H-pyrrole-3-carboxylic acid;bis(N-[2-(diethylaMino)ethyl]-5-[(5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene)Methyl]-2,4-diMethyl-1H-pyrrole-3-carbox
• CAS NO: 342641-94-5
• Molecular Formula: C₂₂H₂₇FN₄O₂
• Molecular Weight: 398.47
• Mol File: 342641-94-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 572.136 °C at 760 mmHg
• Flash Point: 299.818 °C
• Appearance: /
• Density: 1.23 g/cm³
• Refractive Index: 1.611
• CAS DataBase Reference: N-(2-(Diethylamino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-(Diethylamino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide(342641-94-5)
• EPA Substance Registry System: N-(2-(Diethylamino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide(342641-94-5)

Safety Data

• Hazardous Substances Data: 342641-94-5(Hazardous Substances Data)

Usage

General Description

N-(2-(Diethylamino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide is a complex organic compound composed of fluorine, nitrogen, carbon, hydrogen, and oxygen atoms. This chemical belongs to the class of organic compounds known as indolinones, which are indoles in which the nitrogen atom is part of a ketone group. Due to its structure, the compound may have potential biological activities, but there is not enough research to confirm its specific properties and uses. The compound can be categorized into subgroups including pyrroles and amides, which can typically be found in many types of medications and drugs.

InChI:InChI=1/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)

Upstream product

• 56341-41-4 5-fluoroindol-2(3H)-one 
• 356068-86-5 N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide 
• 68-12-2 N,N-dimethyl-formamide 
• 590424-05-8 N-[2-(diethylamino)ethyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide 
• 253870-02-9 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid 
• 452105-33-8 5-((5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid 
• 100-36-7 N,N-diethylethylenediamine 

Downstream Products

• 499220-14-3 sunitinib malate 

Relevant articles and documents

Malic acid lin's preparation method

The present invention relates to a sunitinib malate preparation method, wherein particularly 2,4-dimethyl-5-aldehyde-1H-pyrrole-3-carboxylic acid is adopted as a starting raw material, carboxyl activation with carbonyl diimidazole is performed, the obtained material and N, N-diethylethylenediamine are subjected to condensation under catalysis of 1-hydroxybenzotriazole to obtain an intermediate 1, the intermediate 1 and 5-fluoro-2-oxindole react to obtain sunitinib, and the sunitinib and malic acid are directly subjected to salifying without separation so as to obtain the target product. The method of the present invention has characteristics of easy operation, high yield and high product purity, and is suitable for industrial production.

Method for recovering and utilizing byproduct of chlorination of phosphorus pentachloride

The invention relates to a technology for comprehensively utilizing the byproduct of chlorination of phosphorus pentachloride, and mainly relates to a post treatment, which scientifically utilizes the excess phosphorus pentachloride reagent. The byproduct is converted into an organic synthesis reagent with a wide application range. The wastes are converted into a valuable resource. The discharge of waste water, waste gas, and waste solid is reduced. The obtained reagent is an excellent active reagent, which is widely used in the chemical industry, pharmacy industry, and material industry. The production cost is reduced, and the environment is protected.

NOVEL SALTS OF SUNITINIB

The present invention relates to novel pharmaceutically acceptable salts of sunitinib, to processes for their preparation and to pharmaceutical compositions containing them.