- Synthesis method of high-purity chloroquine phosphate
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The invention relates to the technical field of medicine synthesis, in particular to a synthesis method of chloroquine phosphate, and particularly provides a synthesis method of high-purity chloroquine phosphate. The synthesis method comprises the following steps: (1) condensation: reacting 4, 7-dichloroquinoline with 2-amido-5-diethylamine pentane to obtain a chloroquine crude product; and (2) refining: recrystallizing to obtain chloroquine with higher purity. (3) salifying: stirring and crystallizing the refined chloroquine and phosphoric acid for 2-3 hours, and filtering to obtain a chloroquine phosphate crude product; and (4) purification: recrystallizing the chloroquine phosphate crude product to obtain high-purity chloroquine phosphate. The method is high in atom utilization rate, high in yield, high in product purity, less in solid waste, beneficial to environmental protection and convenient for industrial application, and has a relatively good industrial prospect.
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Paragraph 0043; 0048-0053; 0058-0062; 0067-0070; 0076-0077
(2021/02/10)
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- Preparation process of chloroquine phosphate (by machine translation)
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The invention discloses a preparation process of chloroquine phosphate. The preparation process of the chloroquine phosphate comprises the following steps: (1) condensation reaction with 4,7 -amino 2 - diethylamino-pentane, and basifying and extracting to obtain chloroquine; (-5 -) synthesizing chloroquine and phosphoric acid obtained in the step (2 1) to obtain chloroquine phosphate. To the preparation process of chloroquine phosphate provided by the invention, the use of other catalysts such as benzene and other catalysts is avoided in the preparation process, the product purity is high, the single impurity is less than 0.1%, the operation is simple, the procedures are simplified, the production efficiency is improved, and the method is suitable for industrial production. (by machine translation)
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Paragraph 0041; 0043-0045; 0047-0049; 0051-0053; 0055-0057
(2020/09/23)
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