- METHOD FOR PRODUCING FLUOROAMINE
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Provided is a one-step efficient production method for an α,α-difluoroamine of a general formula (1) from an amide compound. The method is an economical method capable of producing the intended α,α-difluoroamine at high yield by reacting a starting amide
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Page/Page column 6-7
(2009/04/23)
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- A facile synthesis of oxazolines, thiazolines, and imidazolines using α,α-difluoroalkylamines
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β-Amino alcohols, β-amino thiols, and β-diamines can be converted to the corresponding oxazoline, thiazoline, and imidazoline derivatives, respectively, by reaction with α,α-difluoroalkylamines under mild conditions. The reaction is applicable for the synthesis of optically active heterocyclic compounds. Georg Thieme Verlag Stuttgart.
- Fukuhara, Tsuyoshi,Hasegawa, Chihiro,Hara, Shoji
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p. 1528 - 1534
(2008/02/05)
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- PROCESS FOR PRODUCING ALPHA, ALPHA- DIFLUOROAMINE
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A process for producing an α,α-difluoroamine which comprises using hydrogen fluoride and a Lewis base in specific amounts in the halogen-fluorine exchange reaction using an α,α-dihaloamine as the substrate. The process can be industrially applied, enables to obtain the object compound in a short time at a great yield and can be conducted easily with excellent productivity.
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- PROCESS FOR PRODUCING α,α-DIFLUOROAMINE
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An industrially practicable process for producing an α,α-difluoroamine, which comprises using specific amounts of hydrogen fluoride and a Lewis base in a halogen-fluorine exchange reaction in which an α,α-dihaloamine is used as a substrate. The process enables the target compound to be obtained in a short time and a high yield. It is easy and has excellent productivity.
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Page/Page column 12-14
(2008/06/13)
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- PROCESS FOR PRODUCING OPTICALLY ACTIVE FLUOROCHEMICAL
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The present invention provides a process for producing an optically active fluoro compound represented by formula (3) through reaction between a specific fluoroamine and an optically active diol; and a process for producing an optically active fluoroalcoh
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Page/Page column 6
(2008/06/13)
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- Synthesis of gem-difluorides from aldehydes using DFMBA
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Synthesis of gem-difluorides from aldehydes was effectively achieved using DFMBA and Et3N-3HF under microwave irradiation or conventional thermal heating. Both aromatic and aliphatic aldehydes could be converted to the corresponding gem-difluor
- Furuya, Tsukasa,Fukuhara, Tsuyoshi,Hara, Shoji
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p. 721 - 725
(2007/10/03)
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- METHOD OF FLUORINATION
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A method of fluorination comprising reacting monosaccharides, oligosaccharides, polysaccharides, composite saccharides formed by bonding of these saccharides with proteins and lipids and saccharides having polyalcohols, aldehydes, ketones and acids of the polyalcohols, and derivatives and condensates of these compounds with a fluorinating agent represented by general formula (I) thermally or under irradiation with microwave or an electromagnetic wave having a wavelength around the microwave region. In accordance with the method, the fluorination at a selected position can be conducted safely at a temperature in the range of 150 to 200°C where the reaction is difficult in accordance with conventional methods. The above method comprising the irradiation with microwave or an electromagnetic wave having a wavelength around the microwave region can be applied to substrates other than saccharides. When a complex compound comprising HF and a base is reacted under irradiation with microwave, fluorination at a specific position which is difficult in accordance with conventional methods proceeds highly selectively, efficiently in a short time and safely.
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Page/Page column 9
(2008/06/13)
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- Fluorine compound and fluorinating agent comprising the compound
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A fluorine compound represented by Formula (1) is provided. The above fluorine compound is effective for introducing a fluorine atom into a compound having an active group such as an oxygen-containing functional group, and it can be used for uses of surface treatment, cleaning and coating. Further, after the fluorination reaction, the above compound is recovered and can be reused as a starting material for producing the above fluorine compound, and it is useful for various fluorination processes. (wherein X represents a nitrogen or phosphorus atom; R0, R1, and R2 represent hydrogen, an alkyl group or aryl group which may have a substituent, and they each may be the same or different; and R0, R1, and R2 may be combined with each other to form a ring).
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