501433-14-3

Basic information

• Product Name: Methyl 2,6-Difluoro-3-iodobenzoate
• Synonyms: Methyl 2,6-Difluoro-3-iodobenzoate
• CAS NO: 501433-14-3
• Molecular Formula: C₈H₅F₂IO₂
• Molecular Weight: 298.0253764
• Mol File: 501433-14-3.mol

Chemical Properties

• Boiling Point: 300.2±42.0 °C(Predicted)
• Appearance: /
• Density: 1.888±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: Methyl 2,6-Difluoro-3-iodobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2,6-Difluoro-3-iodobenzoate(501433-14-3)
• EPA Substance Registry System: Methyl 2,6-Difluoro-3-iodobenzoate(501433-14-3)

Safety Data

• Hazardous Substances Data: 501433-14-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 2,6-Difluoro-3-iodobenzoate is used as a building block for the synthesis of various pharmaceuticals. Its unique chemical properties and high reactivity make it a valuable intermediate in the development of new drugs.
Used in Agrochemical Industry:
Methyl 2,6-Difluoro-3-iodobenzoate is also used as a building block for the synthesis of agrochemicals. Its reactivity and unique properties contribute to the development of effective and innovative agrochemical products.
Used in Materials Science:
Methyl 2,6-Difluoro-3-iodobenzoate is used in the development of new materials due to its unique chemical properties. Its reactivity and functional groups make it a promising candidate for the creation of advanced materials with specific properties.
It is important to handle Methyl 2,6-Difluoro-3-iodobenzoate with care, as it is a hazardous chemical that may cause irritation and harm to human health and the environment if not properly managed.

Upstream product

• 67-56-1 methanol 
• 229178-74-9 2,6-difluoro-3-iodobenzoic acid 
• 2265-92-1 1,4-difluoro-2-iodobenzene 
• 372-18-9 1,3-Difluorobenzene 
• 385-00-2 2,6-difluorobenzoic acid 
• 124-38-9 carbon dioxide 
• 13697-89-7 2,6-difluoroiodobenzene 
• 186581-53-3 diazomethane 
• 501432-99-1 1,4-difluoro-2,3-diiodobenzene 

Downstream Products

• 1163692-55-4 C₁₂H₁₅FINO₃ 
• 1163692-56-5 C₁₂H₁₅FINO₃ 
• 1338560-92-1 6-(3-chloro-2-fluorobenzyl)-5-hydroxy-4-oxo-1-p-tolyl-1,4-dihydroquinoline-3-carboxylic acid 
• 1338561-48-0 C₂₄H₁₄ClF₄NO₃ 
• 1338561-47-9 C₂₄H₁₅ClF₃NO₃ 
• 1338561-46-8 C₂₄H₁₅ClF₃NO₃ 
• 1338560-91-0 6-(3-chloro-2-fluorobenzyl)-5-hydroxy-4-oxo-1-m-tolyl-1,4-dihydroquinoline-3-carboxylic acid 
• 1338561-45-7 C₂₄H₁₅ClF₃NO₃ 
• 1338561-44-6 C₂₄H₁₆F₃NO₃ 
• 1338561-43-5 C₂₅H₁₈ClF₂NO₃ 
• 1338561-42-4 C₂₄H₁₆ClF₂NO₃ 
• 1338561-40-2 C₂₄H₁₇F₂NO₃ 
• 1338561-38-8 C₂₄H₁₆BrClFNO₄ 
• 1338561-37-7 C₂₆H₂₁ClFNO₄ 

Relevant articles and documents

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Six different fluoroarenes were submitted to the same transformations. Direct deprotonation with alkyllithium or lithium dialkylamide as reagents and subsequent carboxylation afforded the acids 1, 6, 11, 16, 18, and 23. If the aryllithium intermediate was trapped with iodine rather than with dry ice, an iodofluoroarene (2, 7, 12, 17, 19, and 24) was formed. This, upon treatment with lithium diisopropylamide, underwent deprotonation and iodine migration. The resulting new aryllithium species was intercepted either by carboxylation, to give the acids 3, 8, 13, 20, and 25, or by neutralization, to produce the iodofluoroarenes 4, 9, 14, 21, and 26. The latter family of compounds was converted into another set of acids 5, 10, 15, 22, and 27 by subsequent treatment with butyllithium or isopropylmagnesium chloride and carbon dioxide. ( Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002).