Carbethoxylating Agents as Inhibitors of Aldehyde Dehydrogenase
N,O-Dicarbethoxy-4-chlorobenzenesulfohydroxamate (1c) and O-carbethoxy-N-hydroxysaccharin (6), both potential carbethoxylating agents, inhibited yeast aldehyde dehydrogenase (AlDH) with IC50's of 24 and 56 μM, respectively.The esterase activity of the enz
Nagasawa, Herbert T.,DeMaster, Eugene G.,Goon, David J. W.,Kawle, Sagar P.,Shirota, Frances N.
N-Hydroxy sulfonamides as new sulfenylating agents for the functionalization of aromatic compounds
An unprecedented use of N-hydroxy sulfonamides as sulfenylating agents has been established. In the presence of catalytic amounts of iodine and N-hydroxysuccinimide, N-hydroxy sulfonamides participated in sulfenylation with indoles, 7-azaindole, N-methyl pyrrole, and 2-naphthol to afford structurally diverse thioethers in moderate to excellent yields with very high regioselectivity.