Carbethoxylating Agents as Inhibitors of Aldehyde Dehydrogenase

DOI: 10.1021/jm00011a006

Source and publish data:

Journal of Medicinal Chemistry p. 1872 - 1876 (1995)

Update date:2022-08-11

Topics:

Authors:

Nagasawa, Herbert T.

DeMaster, Eugene G.

Goon, David J. W.

Kawle, Sagar P.

Shirota, Frances N.

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Article abstract of DOI:10.1021/jm00011a006

N,O-Dicarbethoxy-4-chlorobenzenesulfohydroxamate (1c) and O-carbethoxy-N-hydroxysaccharin (6), both potential carbethoxylating agents, inhibited yeast aldehyde dehydrogenase (AlDH) with IC50's of 24 and 56 μM, respectively.The esterase activity of the enz

Full text of DOI:10.1021/jm00011a006

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