50695-53-9

Basic information

• Product Name: 4-chloro-N-hydroxybenzenesulfonamide
• CAS NO: 50695-53-9
• Molecular Formula: C₆H₆ClNO₃S
• Molecular Weight: 207.6347
• Mol File: 50695-53-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 376.4°C at 760 mmHg
• Flash Point: 181.4°C
• Density: 1.561g/cm³
• Vapor Pressure: 2.47E-06mmHg at 25°C
• Refractive Index: 1.601
• CAS DataBase Reference: 4-chloro-N-hydroxybenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-N-hydroxybenzenesulfonamide(50695-53-9)
• EPA Substance Registry System: 4-chloro-N-hydroxybenzenesulfonamide(50695-53-9)

Safety Data

• Hazardous Substances Data: 50695-53-9(Hazardous Substances Data)

Upstream product

• 98-60-2 4-chlorobenzenesulfonyl chloride 

Downstream Products

• 75732-34-2 N-(p-chlorobenzenesulfonyl)-N,O-bis(trimethylsilyl)hydroxylamine 
• 56410-10-7 Z-Gly-OV 
• 32884-73-4 3-((4-chlorophenyl)thio)-1H-indole 
• 14725-82-7 methyl 3-((4-chlorophenyl)sulfonyl)propanoate 
• 142867-53-6 N-benzoyl-N-(benzoyloxy)-4-chlorobenzenesulfonamide 
• 142867-52-5 N-acetyl-N-(acetyloxy)-4-chlorobenzenesulfonamide 

Relevant articles and documents

Studies on peptides. XXXVII. Suppressed racemization in peptide synthesis by the use of p chloro or p nitrobenzenesulfohydroxamic acid

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N-Hydroxy sulfonamides as new sulfenylating agents for the functionalization of aromatic compounds

An unprecedented use of N-hydroxy sulfonamides as sulfenylating agents has been established. In the presence of catalytic amounts of iodine and N-hydroxysuccinimide, N-hydroxy sulfonamides participated in sulfenylation with indoles, 7-azaindole, N-methyl pyrrole, and 2-naphthol to afford structurally diverse thioethers in moderate to excellent yields with very high regioselectivity.