- NUCLEIC ACID-BINDING PHOTOPROBES AND USES THEREOF
-
The present invention relates to photoactivatable compounds and methods of use thereof for determining binding site and other structural information about RNA transcripts. The invention also provides methods of identifying RNA transcripts that bind compounds and are thus druggable, methods of screening drug candidates, and methods of determining drug binding sites and/or accessible or reactive sites on a target RNA.
- -
-
Paragraph 0042
(2019/06/17)
-
- COMPOUNDS AND METHODS FOR MODULATING RNA FUNCTION
-
The present invention provides compounds, compositions thereof, and methods of using the same.
- -
-
Paragraph 0068; 00629
(2018/02/28)
-
- POLYCYCLIC TLR7/8 ANTAGONISTS AND USE THEREOF IN THE TREATMENT OF IMMUNE DISORDERS
-
The present invention relates to compounds of Formula (I) and pharmaceutically acceptable compositions thereof, useful as toll-like receptor 7/8 (TLR7/8) antagonists. In Formula (I), Ring A is aryl or heteroaryl; Ring B is aryl or heteroary; and X is C(R4)2, O, NR4, S, S(R4), or S(R4)2.
- -
-
Paragraph 00229; 00231
(2017/07/06)
-
- COMPOUNDS AND METHODS OF TREATING RNA-MEDIATED DISEASES
-
The present invention provides compounds, compositions thereof, and methods of using the same.
- -
-
Sheet 97/122
(2017/12/27)
-
- CCR6 COMPOUNDS
-
Compounds of formula (I) are provided which are useful in the treatment of diseases or conditions modulated at least in part by CCR6. Pharmaceutical compositions of the compounds of formula (I) are also provided. Further provided in the present disclosure
- -
-
Paragraph 0114
(2015/06/18)
-
- SELECTIVELY SUBSTITUTED QUINOLINE COMPOUNDS
-
Embodiments of the disclosure relate to selectively substituted quinoline compounds of formula (I) that act as antagonists or inhibitors for Toll -like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic
- -
-
Paragraph 0069;0083; 0085
(2015/05/05)
-
- SELECTIVELY SUBSTITUTED QUINOLINE COMPOUNDS
-
Embodiments of the disclosure relate to selectively substituted quinoline compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.
- -
-
Paragraph 0168; 0184
(2015/04/21)
-
- PIPERAZINE DERIVATIVES AND THEIR USE AS MODULATORS OF NUCLEAR HORMONE RECEPTOR FUNCTION
-
The present invention provides piperazine derivatives and methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders.
- -
-
Page/Page column 79
(2010/02/11)
-