50846-36-1

Basic information

• Product Name: 2-AMINO-2-METHYL-PROPIONITRILE HYDROCHLORIDE
• Synonyms: 2-AMINO-2-METHYL-PROPIONITRILE HYDROCHLORIDE;alpha-Aminoisobutyronitrile hydrochloride;2-AMino-2-Methylpropanenitrile HCl;Propanenitrile, 2-aMino-2-Methyl-, Monohydrochloride;2-AMino-2-Methylpropaneitrile hydrochloride
• CAS NO: 50846-36-1
• Molecular Formula: C₄H₈N₂*ClH
• Molecular Weight: 120.58
• EINECS: 1308068-626-2
• Mol File: 50846-36-1.mol

Chemical Properties

• Melting Point: 147-149℃
• Appearance: /
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 2-AMINO-2-METHYL-PROPIONITRILE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-2-METHYL-PROPIONITRILE HYDROCHLORIDE(50846-36-1)
• EPA Substance Registry System: 2-AMINO-2-METHYL-PROPIONITRILE HYDROCHLORIDE(50846-36-1)

Safety Data

• Hazardous Substances Data: 50846-36-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Amino-2-methyl-propionitrile hydrochloride is used as an intermediate for the synthesis of various pharmaceuticals. It plays a crucial role in the production of drugs due to its ability to be incorporated into complex molecular structures, contributing to the development of new medications.
Used in Agrochemical Industry:
In the agrochemical sector, 2-amino-2-methyl-propionitrile hydrochloride is utilized as an intermediate in the manufacturing process of different agrochemicals. Its properties make it suitable for the creation of compounds that can be used in pest control and crop protection.
Used in Organic Synthesis:
2-Amino-2-methyl-propionitrile hydrochloride is used as a building block in organic synthesis for the preparation of other organic compounds. Its reactivity and functional groups make it a valuable component in the synthesis of a wide range of organic molecules.
Used as a Reagent in Chemical Industry:
Furthermore, 2-amino-2-methyl-propionitrile hydrochloride has the potential to be used as a reagent in the synthesis of new chemical entities. Its application in the chemical industry allows for the exploration and creation of innovative materials and compounds for various purposes.

Upstream product

• 67-64-1 acetone 
• 19355-69-2 2-amino-2-cyanopropane 
• 151-50-8 potassium cyanide 

Downstream Products

• 79662-84-3 (1-Cyan-1-methylethyl)harnstoff 
• 100134-82-5 (cyano-dimethyl-methyl)carbamic acid benzyl ester 
• 1258444-79-9 (1R,2R,4R)-4-benzenesulfonyl-2-(morpholine-4-carbonyl)cyclopentanecarboxylic acid (cyanodimethylmethyl)amide 
• 1026308-88-2 N-(1-cyano-1-methyl-ethyl)-4-methoxybenzamide 
• 2582-16-3 2,2,5,5-tetramethylimidazolidine-4-thione 
• 16252-90-7 2-amino-2-methylpropanamide 
• 1749-99-1 4-imino-5,5-dimethylimidazolidin-2-one 

Relevant articles and documents

Prebiotically Plausible Organocatalysts Enabling a Selective Photoredox α-Alkylation of Aldehydes on the Early Earth

Organocatalysis is a powerful approach to extend and (enantio-) selectively modify molecular structures. Adapting this concept to the Early Earth scenario offers a promising solution to explain their evolution into a complex homochiral world. Herein, we present a class of imidazolidine-4-thione organocatalysts, easily accessible from simple molecules available on an Early Earth under highly plausible prebiotic reaction conditions. These imidazolidine-4-thiones are readily formed from mixtures of aldehydes or ketones in presence of ammonia, cyanides and hydrogen sulfide in high selectivity and distinct preference for individual compounds of the resulting catalyst library. These organocatalysts enable the enantioselective α-alkylation of aldehydes under prebiotic conditions and show activities that correlate with the selectivity of their formation. Furthermore, the crystallization of single catalysts as conglomerates opens the pathway for symmetry breaking.

Facile one-pot synthesis of 5-substituted hydantoins

5-Substituted and 5,5-disubstituted hydantoins are synthesised from the corresponding aldehydes or ketones, using a one-pot, gallium(iii) triflate-catalysed procedure that is compatible with a range of substrates and solvents.

CATHEPSIN INHIBITORS

This invention relates to a novel class of compounds, represented by the formula (I) below, wherein the meanings of R1, R2, R3 and R4 are indicated therein, which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis, osteoarthritis and rheumatoid arthritis.

Dipeptide nitriles

N-terminal substituted dipeptide nitriles as defined are useful as inhibitors of cysteine cathepsins, e.g. cathepsins B, K, L and S, and can be used for the treatment of cysteine cathepsin dependent diseases and conditions, including inflammation, rheumatoid arthritis, osteoarthritis, osteoporosis, tumors (especially tumor invasion and tumor metastasis), coronary disease, atherosclerosis (including atherosclerotic plaque rupture and destabilization). Particular dipeptide nitriles are compounds of formula I, or physiologically-acceptable and -cleavable esters or a salts thereof wherein: the symbols are as defined. In particular it has been found that by appropriate choice of groups R, R2, R3, R4, R5, X1, Y and L, the relative selectivity of the compounds as inhibitors of the various cysteine cathepsin types, e.g. cathepsins B, K, L and S may be altered, e.g. to obtain inhibitors which selectively inhibit a particular cathepsin type or combination of cathepsin types.

Preparation of α-aminothioamides from aldehydes

The conversion of aldehydes into α-aminonitriles and thence into imidazolidin-4-thiones has been studied.Hydrolysis of the appropriate imidazolidin-4-thiones gave thioamides of nine naturally occuring α-amino acids.The possible pre-biotic significance of these compounds is discussed.