Regioselective alkylation of saccharin with alcohols under Mitsunobu conditions
The regioselective Mitsunobu alkylation of saccharin with various alcohols has been examined. The N/O-alkylation is dependent on the steric hindrance of the alcohols, that is, less sterically hindered alcohol preferentially afford N-alkylated saccharin an
Wang, Xiaolong,Ma, Yanying,Ju, Tingting
p. 417 - 419
(2013/09/12)
Sulfonamide ligands attained through opening of saccharin derivatives
Literature N-alkylsaccharins (saccharin-R2) have been shown in some cases to be O-alkylated regioisomers by crystallography (3 structures). The genuine former species react with (S)-H2NCHR1CH 2OH at 101°C in dio
Robinson, Richard I.,Fryatt, Ross,Wilson, Claire,Woodward, Simon
p. 4483 - 4489
(2007/10/03)
Metal-assisted reactions. Part 27. 3-benzyloxy-1,2-benzisothiazole 1,1-dioxide: An unusual ether linkage that does not permit heterogeneous catalytic hydrogenolysis
Aryl or allyl ethers of some heterocyclic systems can be readily hydrogenolysed or cross-coupled catalytically with transition metals to give arenes, alkenes or alkanes. Unexpectedly for transition metals, the corresponding alkyl and, particularly, benzyl
Brigas, Amadeu F.,Goncalves, Pedro M.,Johnstone, Robert A. W.
p. 2603 - 2605
(2007/10/03)
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