Studies on organophosphorus compounds 55. A new and facile synthetic route to 1-alkyl(aryl)-2-amino-1-hydroxyalkylphosphonic acids
Nucleophilic addition of dimethyl phosphite to acylamino ketones prepared conveniently by the Dakin-West reaction involving reaction of the corresponding α-amino acids and acid anhydrides, followed by subsequent hydrolysis affords 1-alkyl(aryl)-2-amino-1-hydroxyalkylphosphonic acids in satisfactory yield.
Yuan,Chen
p. 531 - 532
(2007/10/02)
STUDIES ON ORGANOPHOSPHORUS COMPOUNDS 54. SYNTHESIS OF 1-HYDROXY-1-ALKYL(ARYL)-2-AMINOETHYLPHOSPHONIC ACIDS AND DERIVATIVES THEREOF
An improved method is developed for the synthesis of 1-hydroxy-1-alkyl(aryl)-2-aminoethylphosphonic acids based on hydrogenation of dialkyl 1-hydroxy-1-alkyl(aryl)-2-nitroethylphosphonates over Raney nickel in acidic medium followed by hydrolysis.The inst
Yuan, Chengye,Wang, Guohong,Shoujun, Chen,Maier, Ludwig
p. 111 - 118
(2007/10/02)
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