- N-CONTAINING CHROMEN-4-ONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION
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The present invention provides the compounds having the general formula: (I) wherein R1 to R8, and X are as described herein, compositions including the compounds and methods of using the compounds.
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Page/Page column 94; 95
(2020/07/07)
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- NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS
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The present invention discloses compounds according to Formula I: Wherein R 1a, R 1b, R 2, R 4, R5, R 6, R 7, R 8, W, X, Y, Z, Cy, and the subscript a are as defined h
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Paragraph 00484
(2015/01/07)
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- HYDANTOIN AND THIOHYDANTOIN DERIVATIVES AS ANTIVIRAL DRUGS
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The present invention relates to a compound of the following formula (I), or a salt, solvate, tautomer, enantiomer, diastereoisomer or racemic mixture thereof: as well as its use as a drug, notably in the treatment of hepatitis C, its preparation process, and the pharmaceutical compositions containing such a compound.
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Page/Page column 185
(2013/12/03)
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- PURINE COMPOUNDS AS HSP90 PROTEIN INHIBITORS FOR THE TREATMENT OF CANCER
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Compounds of formula (I) are inhibitors of HSP90, and of utility in the treatment of, for example, cancers: wherein ring A is an aryl or heteroaryl ring or ring system; R1 is hydrogen, fluoro, chloro, bromo, or a radical of formula (1A): -X-AIk
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Page/Page column 60-61
(2008/06/13)
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- HYDROFORMYLATION PROCESS FOR THE CONVERSION OF AN ETHYLENICALLY UNSATURATED COMPOUND TO AN ALCOHOL
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The invention pertains to a hydroformylation process for the conversion of an ethylenically unsaturated compound to an alcohol comprising a first step of reacting at an elevated temperature in a reactor the ethylenically unsaturated compound, carbon monox
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- NEW SYNTHETIC APPROACH TO 1-AZABICYCLOALKANE SKELETONS FROM β-ENAMINO DIESTERS DERIVED FROM MELDRUM'S ACID
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Two complementary methods for the synthesis of title compounds (4 and 6), namely, monodecarboxylating transesterification of β-enamino esters 2 followed by intramolecular cyclization of 3, and direct cyclization of 2 under flash vacuum thermolysis conditions, have been elaborated.Further investigations allowed the identification of β-enamino acid chloride 5 as a stable intermediate in the direct cyclization of 2 into 6.Azabicyclic compounds 4 were stereospecifically converted to bicyclic β-amino alcohols 9 by means of stereocontrolled carbon-carbon double bondcatalytic hydrogenation followed by ester moiety reduction.
- Haddad, Mansour,Celerier, Jean Pierre,Haviari, Gjergj,Lhommet, Gerard,Dhimane, Hamid,at al.
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p. 1251 - 1260
(2007/10/02)
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- β-ENAMINOESTERS BICYCLIQUES : SYNTHESE ET REDUCTION STEREOSPECEFIQUES. ACCES A L'ISORETRONECANOL, LA TRACHELANTHAMIDINE, LA LUPININE ET L'EPILUPININE
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The functionalized N-alkyl-β-enaminoesters 11 are precursore of nitrogen-bridged bicyclic β-enaminoesters 7.The compounds 7 are prepared either by intramolecular alkylation of β-enaminoesters 11 or by termolysis of β-enaminoesters 6.A stereospecific reduction of 7 under thermal control leads to bicyclic β-aminoesters 13, 14, 15 or 16 which are good precursors of natural aminoalcohols like lupinine 4 or isoretronecanol 2.
- Celerier, J. P.,Haddad, M.,Saliou, C.,Lhommet, G.
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p. 6161 - 6170
(2007/10/02)
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- Manufacture of haloalkyl lactams
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A process for the manufacture of haloalkyl lactams having the formula STR1 wherein n is an integer having a value of from 1 to 3; m is an integer having a value of 1 or 2 and X is chlorine or bromine in the absence of an inert solvent by reacting a hydroxyalkyl lactam of the formula STR2 with a thionyl chloride or bromide in the liquid phase under anhydrous conditions, vaporizing and removing any excess thionyl halide along with SO2 by-product from the liquid reaction mixture under vacuum followed by vacuum distillation of the remaining liquid product mixture at a temperature below its decomposition and recovering said product. The product of this process can be obtained in greater than 90% yield and 99% purity.
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