51333-90-5

Usage

Uses

Used in Pharmaceutical Industry:
1-(2-CHLORO-ETHYL)-PYRROLIDIN-2-ONE is used as a chemical intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical sector, 1-(2-CHLORO-ETHYL)-PYRROLIDIN-2-ONE serves as a precursor in the production of agrochemicals, aiding in the creation of pesticides and other agricultural chemicals to protect crops and enhance yield.
Used in Plastics and Resin Industry:
1-(2-CHLORO-ETHYL)-PYRROLIDIN-2-ONE is utilized as a key component in the manufacturing process of plastics and resins, enhancing their properties and expanding their applications in various industries.
Used in Specialty Chemicals Production:
1-(2-CHLORO-ETHYL)-PYRROLIDIN-2-ONE is also employed in the production of specialty chemicals, where its unique properties are leveraged to create high-value chemical products for specific applications.

Upstream product

• 3445-11-2 1-(2-hydroxyethyl)-2-pyrrolidinone 
• 616-45-5 2-pyrrolidinon 
• 107-04-0 1-Bromo-2-chloroethane 
• 96-48-0 4-butanolide 
• 141-43-5 ethanolamine 

Downstream Products

• 88-12-0 1-ethenyl-2-pyrrolidinone 
• 13839-15-1 1-(2-mercapto-ethyl)-pyrrolidin-2-one 
• 7435-92-9 trimethyl-[2-(2-oxo-pyrrolidino)-ethyl]-ammonium; iodide 
• 930298-36-5 1-(2-{2,4-dichloro-5-[2-chloro-9-(4-methoxy-benzyl)-9H-purin-6-yl]-phenoxy}-ethyl)-pyrrolidin-2-one 
• 54506-42-2 1-{2-[4-(8-chloro-2-methyl-10,11-dihydro-dibenzo[b,f]thiepin-10-yl)-piperazin-1-yl]-ethyl}-pyrrolidin-2-one 
• 3001-72-7 DBN 
• 24299-77-2 methyl 3-(2'-oxo-1'-pyrrolidinyl)propanoate 
• 77191-38-9 3-(2-oxopyrrolidin-1-yl)propionic acid 
• 3445-11-2 1-(2-hydroxyethyl)-2-pyrrolidinone 
• 117018-92-5 N--2-pyrrolidone hydrochloride 
• 104087-51-6 1-(2-{4-[(1R,3S)-6-Fluoro-3-(4-fluoro-phenyl)-indan-1-yl]-piperazin-1-yl}-ethyl)-pyrrolidin-2-one 

Relevant academic research and scientific papers

N-CONTAINING CHROMEN-4-ONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION

The present invention provides the compounds having the general formula: (I) wherein R1 to R8, and X are as described herein, compositions including the compounds and methods of using the compounds.

NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS

The present invention discloses compounds according to Formula I: Wherein R 1a, R 1b, R 2, R 4, R5, R 6, R 7, R 8, W, X, Y, Z, Cy, and the subscript a are as defined h

HYDANTOIN AND THIOHYDANTOIN DERIVATIVES AS ANTIVIRAL DRUGS

The present invention relates to a compound of the following formula (I), or a salt, solvate, tautomer, enantiomer, diastereoisomer or racemic mixture thereof: as well as its use as a drug, notably in the treatment of hepatitis C, its preparation process, and the pharmaceutical compositions containing such a compound.

PURINE COMPOUNDS AS HSP90 PROTEIN INHIBITORS FOR THE TREATMENT OF CANCER

Compounds of formula (I) are inhibitors of HSP90, and of utility in the treatment of, for example, cancers: wherein ring A is an aryl or heteroaryl ring or ring system; R1 is hydrogen, fluoro, chloro, bromo, or a radical of formula (1A): -X-AIk

HYDROFORMYLATION PROCESS FOR THE CONVERSION OF AN ETHYLENICALLY UNSATURATED COMPOUND TO AN ALCOHOL

The invention pertains to a hydroformylation process for the conversion of an ethylenically unsaturated compound to an alcohol comprising a first step of reacting at an elevated temperature in a reactor the ethylenically unsaturated compound, carbon monox

NEW SYNTHETIC APPROACH TO 1-AZABICYCLOALKANE SKELETONS FROM β-ENAMINO DIESTERS DERIVED FROM MELDRUM'S ACID

Two complementary methods for the synthesis of title compounds (4 and 6), namely, monodecarboxylating transesterification of β-enamino esters 2 followed by intramolecular cyclization of 3, and direct cyclization of 2 under flash vacuum thermolysis conditions, have been elaborated.Further investigations allowed the identification of β-enamino acid chloride 5 as a stable intermediate in the direct cyclization of 2 into 6.Azabicyclic compounds 4 were stereospecifically converted to bicyclic β-amino alcohols 9 by means of stereocontrolled carbon-carbon double bondcatalytic hydrogenation followed by ester moiety reduction.

β-ENAMINOESTERS BICYCLIQUES : SYNTHESE ET REDUCTION STEREOSPECEFIQUES. ACCES A L'ISORETRONECANOL, LA TRACHELANTHAMIDINE, LA LUPININE ET L'EPILUPININE

The functionalized N-alkyl-β-enaminoesters 11 are precursore of nitrogen-bridged bicyclic β-enaminoesters 7.The compounds 7 are prepared either by intramolecular alkylation of β-enaminoesters 11 or by termolysis of β-enaminoesters 6.A stereospecific reduction of 7 under thermal control leads to bicyclic β-aminoesters 13, 14, 15 or 16 which are good precursors of natural aminoalcohols like lupinine 4 or isoretronecanol 2.

Manufacture of haloalkyl lactams

A process for the manufacture of haloalkyl lactams having the formula STR1 wherein n is an integer having a value of from 1 to 3; m is an integer having a value of 1 or 2 and X is chlorine or bromine in the absence of an inert solvent by reacting a hydroxyalkyl lactam of the formula STR2 with a thionyl chloride or bromide in the liquid phase under anhydrous conditions, vaporizing and removing any excess thionyl halide along with SO2 by-product from the liquid reaction mixture under vacuum followed by vacuum distillation of the remaining liquid product mixture at a temperature below its decomposition and recovering said product. The product of this process can be obtained in greater than 90% yield and 99% purity.