515-03-7

Basic information

• Product Name: Sclareol
• Synonyms: (1R,2R,8AS)-DECAHYDRO-1-(3-HYDROXY-3-METHYL-4-PENTENYL)-2,5,5,8A-TETRAMETHYL-2-NAPHTHOL;SCLAREOL;(13r)-labd-14-ene-13-diol;(1r-(1-alpha(r*),2-beta,4a-beta,8a-alpha))-thyl;.alpha.-ethenyldecahydro-2-hydroxy-.alpha.,2,5,5,8a-pentamethyl-,[1R-[1.alpha.(R*),2.beta.,4a.beta1-Naphthalenepropanol;[1theta-[1alpha(theta),2beta,4abeta,8aalpha]]-thyl;1-(3-Hydroxy-3-methyl-4-pentenyl)-2,5,5,8a-tetramethyldecahydro-2-naphthalenol;1-Naphthalenepropanol, alpha-ethenyldecahydro-2-hydroxy-alpha,2,5,5,8a-pentamethyl-, [1R-[1alpha(R*),2beta,4abeta,8aalpha]]-
• CAS NO: 515-03-7
• Molecular Formula: C₂₀H₃₆O₂
• Molecular Weight: 308.5
• EINECS: 208-194-0
• Product Categories: Organics;Natural Plant Extract;Flavors & Fragrances;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors
• Mol File: 515-03-7.mol

Chemical Properties

• Melting Point: 95-100 °C(lit.)
• Boiling Point: 218-220 °C19 mm Hg(lit.)
• Flash Point: 169.112 °C
• Appearance: white fine powder
• Density: 0.954 g/cm³
• Vapor Pressure: 5.36E-08mmHg at 25°C
• Refractive Index: 1.489
• Storage Temp.: 2-8°C
• Solubility: Chlorform, Ethyl Acetate (Slightly)
• PKA: 14.49±0.29(Predicted)
• BRN: 2054148
• CAS DataBase Reference: Sclareol(CAS DataBase Reference)
• NIST Chemistry Reference: Sclareol(515-03-7)
• EPA Substance Registry System: Sclareol(515-03-7)

Safety Data

• WGK Germany: 2
• RTECS: QK0301900
• Hazardous Substances Data: 515-03-7(Hazardous Substances Data)

Usage

Uses

Used in Fragrance Industry:
Sclareol is used as a raw material for the synthesis of ambergris-amber fragrance, particularly suitable for perfume and essence due to its aroma-retaining ability for blending.
Used in Flavor, Spices, and Cosmetics Industry:
Sclareol is utilized in the flavor, spices, cigarettes, cosmetics, health food, and food additives industries for its unique aroma and properties.
Used in Biological Studies:
In the field of biological studies, Sclareol is used for its anti-inflammatory activity in both lipopolysaccharide-stimulated macrophages and λ-carrageenan-induced paw edema model.
Used in Synthesis of Fragrance Chemicals:
Sclareol may be used as a starting material in the synthesis of ambergris fragrance chemicals such as ambraoxide, ambrox, methylambraoxide, ambracetal, ambraketal, and epiambraketal. It may also be used in the synthesis of (+)-galanolactone, (-)-8-epi-galanolactone, and (+)-labdienedial.
Used in Medicine:
In the medical field, Sclareol is used for its anti-bacterial, anti-inflammatory, cholagogue, and anti-cancer properties.
Used in Pesticides:
Sclareol is employed in the pesticides industry for the prevention and control of crop rust, powdery mildew, and as an insecticide. It also mediates the activity of plant growth and plant defense functions.

Salvia

Salvia is also known as Salvia sclar, rosette sage. With biennial or perennial Labiaceae sage, it is about 1 to 2 meters high. With the lower stem lignification, upright, branched, the whole plant is covered with wholly short hairs. It is unifoliate opposite, ovate or oblong. With verticillate inflorescence, the bisexual flowers are pink or pale purple or white. The bracts are broadly ovate, and corolla appears in snow-blue. Nutlets ovoid, grayish brown, smooth. The flowering period from June to July; seeds mature in July. It is a sun-loving plant and resistant to cold, drough and barren, but fear of waterlogging. Seedlings are not resistant to shade. The Origin is southern Europe. China has introduced salvia in the fifties. Now salvias are distributed in Shanxi, Hebei, Henan, Zhejiang and other provinces. The products of salvias which specially grow in the shallow mountainous areas of northern Shanxi, contain high ester aroma and pure, due to the large temperature difference between temperature and humidity in the region, and the altitude which is particularly suitable for the growth of herbal medicine. Salvia has wide adaptability and cold, drought, barren tolerance. Seedlings are afraid of waterlogging, with the ability of living in-8 ℃ to-10 ℃.Adult plants can tolerate the temperature about-25 ℃. Early flowering period needs to have enough water to get high yield. For the seed propagation, the autumn is more suitable. The raw materials of salvia can be harvested in the late June of the following year. It should be planted in the spring, if the growth environment is parks or gardens.

Cytotoxicity

IC50 (μg/mL): 16.6 (HeLa), 32.65 (MCF7),65.2 μM (MG63) (Farimani et al. 2014).

InChI:InChI=1/C20H36O2/c1-7-18(4,21)13-9-16-19(5)12-8-11-17(2,3)15(19)10-14-20(16,6)22/h7,15-16,21-22H,1,8-14H2,2-6H3/t15-,16+,18-,19-,20+/m0/s1

Upstream product

• 105735-95-3 (1R,2R,4aS,8aS)-1-(3-Hydroperoxy-3-methyl-pent-4-enyl)-2,5,5,8a-tetramethyl-decahydro-naphthalen-2-ol 
• 1093-16-9 8α,20α-Epoxy-manool 
• 596-85-0 manool 
• 1158-77-6 8,17-epoxy-14-labden-13-ol 
• 54274-72-5 (R)-5-((1R,2R,4aS,8aS)-2-acetoxy-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl)-3-methylpent-1-en-3-yl acetate 
• 1000876-36-7 labd-13E-en-8α,15-diol diphosphate 
• 1093-16-9 8β,20β-Epoxy-manool 
• 78012-27-8 pinnatol A 

Downstream Products

• 6790-58-5 (-)-ambroxide 
• 4176-94-7 15-nor-8α,13-dihydroxy-14-labdanoic acid 
• 56247-60-0 (13Ξ)-8,13-epoxy-labdan-15-oic acid methyl ester 
• 1216-84-8 (±)-sclareolide 
• 54274-72-5 (R)-5-((1R,2R,4aS,8aS)-2-acetoxy-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl)-3-methylpent-1-en-3-yl acetate 
• 139116-13-5 18α-hydroxy sclareol-18-O-trityl ether 
• 564-20-5 sclareolide 
• 31207-65-5 ((2R,4aS,8aS)-2-Acetoxy-2,5,5,8a-tetramethyl-decahydro-naphthalen-1-yl)-acetic acid 
• 5153-92-4 sclareol oxide 
• 16736-51-9 8-hydroxy-15,16-dinor-labdan-13-one 
• 144102-70-5 (13R,14R)-14-hydroperoxy-13,14-epoxy-15-norlabdan-8α-ol 
• 38419-75-9 (1R,2R,4aS,8aS)-1-(2-hydroxyethyl)-2,5,5,8a-tetramethyl-decahydronaphthalen-2-ol 
• 132796-58-8 labd-14-ene-2α,8α,13β-triol 
• 117015-26-6 8α,13β-dihydroxylabd-14-en-3-one 

Relevant articles and documents

Sclareol and labdenediol diphosphate synthase polypeptides, encoding nucleic acid molecules and uses thereof

Provided are labdenediol diphosphate synthase polypeptides, sclareol synthase polypeptides, nucleic acid molecules encoding the labdenediol diphosphate synthase polypeptides and sclareol synthase polypeptides, and methods of using the labdenediol diphosphate synthase polypeptides, sclareol synthase polypeptides. Also provided are methods for producing labdenediol diphosphate, sclareol and (?)-ambroxide.

A short and efficient synthesis of (+)-totarol

A concise route to multigram quantities of the antibacterial diterpene (+)-totarol (1) is reported. (-)-Sclareol (2) was converted to the target compound 1 using either a six- or a seven-step sequence, while only three steps were required to access (+)-totarol ( 1) starting from (+)-manool (9) or (+)-13-epi-manool (10), respectively. A novel one-pot intramolecular aldol condensation/α-alkylation protocol served as the key operation for streamlining the syntheses of 1. ARKAT-USA, Inc.

A SHORT SYNTHESIS OF AMBROX FROM SCLAREOL

A two-step transformation of sclareol into Ambrox (overall yield 11-12percent) via β-cleavage of an alkoxy radical intermediate is described.

STRUCTURE OF NEW BROMODITERPENES, PINNATOLS, FROM THE MARINE RED ALGA LAURENCIA PINNATA YAMADA

The structure of new bromoditerpenes named pinnatols A, B, C, and D, isolated from the title alga, was determined on the basis of the chemical and spectral data.