51555-87-4

Basic information

• Product Name: THIODIGALACTOSIDE
• Synonyms: THIODIGALACTOSIDE;D-GALACTOPYRANOSYL BETA-D-THIOGALACTOPYRANOSIDE;d-galactopyranosyl-β-d-thiogalactopyranoside;D-Galactopyranosyl-b-D-thiogalactopyranoside;D-Galactopyranosyl-β-D-thiogalactopyranoside ,98%;Galactosyl 1-thiogalactoside;TDG
• CAS NO: 51555-87-4
• Molecular Formula: C₁₂H₂₂O₁₀S
• Molecular Weight: 358.36
• Mol File: 51555-87-4.mol

Chemical Properties

• Appearance: /
• Storage Temp.: −20°C
• Solubility: DMSO (Slightly)
• CAS DataBase Reference: THIODIGALACTOSIDE(CAS DataBase Reference)
• NIST Chemistry Reference: THIODIGALACTOSIDE(51555-87-4)
• EPA Substance Registry System: THIODIGALACTOSIDE(51555-87-4)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 51555-87-4(Hazardous Substances Data)

Usage

Uses

Used in Research Applications:
Thiodigalactoside is used as a research tool for studying the interactions between galectins and their ligands, as well as their roles in cell signaling and carcinogenesis. It helps researchers understand the molecular mechanisms underlying various physiological processes and the development of diseases.
Used in Pharmaceutical Industry:
Thiodigalactoside is used as a potential therapeutic agent for the treatment of high-fat diet-induced obesity development, as it inhibits galectin 1, which plays an essential role in this process. By targeting galectin 1, Thiodigalactoside may help in the development of novel obesity treatments and contribute to the management of obesity-related health issues.
Used in Drug Delivery Systems:
Similar to gallotannin, Thiodigalactoside can also be employed in the development of novel drug delivery systems to enhance its applications and efficacy against specific diseases. Various organic and metallic nanoparticles can be used as carriers for Thiodigalactoside delivery, aiming to improve its delivery, bioavailability, and therapeutic outcomes.

Upstream product

• 19879-84-6 2,3,4,6-tetra-O-acetyl-1-thio-D-galactopyranose 
• 3068-32-4 1-bromo-1-deoxy-2,3,4,6-tetra-O-acetyl-a-D-galactopyranoside 
• 18968-44-0 2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl 2,3,4,6-tetra-O-acetyl-1-thio-β-D-galactopyranoside 

Downstream Products

• 1093376-83-0 bis-(4,6-O-benzylidene-β-D-galactopyranosyl)sulfane 

Relevant articles and documents

Synthesis of diglycosylated (di)sulfides and comparative evaluation of their antiproliferative effect against tumor cell lines: A focus on the nature of sugar-recognizing mediators involved

A mini-library of symmetrical and unsymmetrical diglycosyl (di)sulfides, containing D-galactose, L-fucose and N-acetyl glucosamine units, were synthesized and tested for the antiproliferative activity against cervix carcinoma (HeLa) and melanoma (A375) tumor cell lines as well as healthy fibroblasts (HDF). Comparative analysis of results seems to indicate that the most relevant antiproliferative effect is not primarily influenced by interactions with galectins, as the most cytotoxic compound observed for HeLa and A375 is not a ligand for such receptors. The most active molecules against HeLa and A375 lines also exhibited a good selectivity, showing a low toxicity to HDF cells. Obtained results offer useful indications for future design of structurally simple antitumor molecules based on sugar moieties with bridging sulfur atoms.