- A 4,4 '-di-substituted diphenyl ketone compound and its preparation method
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The invention provides a 4,4'-dibasic benzophenone compound which has a structure shown in the following formula I. The compound can well inhibit activities of an AP-1 protein and an NDM-1 protein and has the IC50 value of 52.93 plus and minus 11.86muM fo
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Paragraph 0039-0041
(2017/04/06)
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- Rh-Catalyzed Synthesis of Coumarin Derivatives from Phenolic Acetates and Acrylates via C-H Bond Activation
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An efficient annulation strategy involving the reaction of phenolic acetates with acrylates in the presence of [Rh2(OAc)4] as catalyst and formic acid as reducing agent, leading to the high yield synthesis of coumarin derivatives, has been developed. The addition of NaOAc as a base increased the yield of the products. The reaction is quite successful for both electron-rich as well as electron-deficient phenolic acetates, affording coumarins with excellent regioselectivity, and proceeds via C-H bond activation proven by deuterium incorporation studies.
- Gadakh, Sunita K.,Dey, Soumen,Sudalai, Arumugam
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p. 11544 - 11550
(2015/12/04)
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- Derivatization of coumarins at the benzenoid ring in aqueous medium
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Some 6-disubstituted, 8-disubstituted, and/6,8-disubstituted compounds have been prepared from coumarin, 7-methylcoumarin, and 3,4-benzocoumarin. The Reimer-Tiemann reaction, Lederer-Manasse reaction, bromination using molecular bromine as well as 2,4,4,6-tetrabromocyclohex-2,5-dien-1-one, Elbs reaction, and diazocoupling have been carried under controlled conditions to obtain various derivatives. Further, several reactions of aldehyde derivatives of these coumarins have been carried on to prepare important functional compounds including some heterocycles. It is noteworthy that these aldehydes behave as phenolic aldehydes under alkaline conditions to undergo the Dakin reaction. The reactions are mostly carried in aqueous media involving a dianionic intermediate and hence fulfill one important criterion of green chemistry.
- Bhunia, Sankar C.,Pal, Sutanuka,Patra, Gopal C.,Pal, Sudhir C.
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p. 1679 - 1688
(2015/02/02)
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- Palladium-catalyzed synthesis of benzofurans and coumarins from phenols and olefins
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Triple C-H functionalization: Palladium-catalyzed synthesis of benzofurans and coumarins by reacting phenols and unactivated olefins is described. The reaction comprises sequential C-H functionalization and shows diverse functional group compatibility. Preliminary mechanistic studies shed light into the possible mechanisms. Copyright
- Sharma, Upendra,Naveen, Togati,Maji, Arun,Manna, Srimanta,Maiti, Debabrata
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supporting information
p. 12669 - 12673
(2013/12/04)
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- Reimer-tiemann reaction of coumarins
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Improved yields of aldehydes from the Reimer-Tiemann reaction of coumarin and two of its derivatives, namely 7-methylcoumarin and 3,4-benzocoumarin, are obtained by carrying the reaction in a two-step procedure. Using crown ether as phase transfer catalyst, a further improvement in the yield of products is achieved. Additionally, coumarin and 7- methylcoumarin are shown to give dialdehydes under this condition. Dialdehydes are reported for the first time from the Reimer-Tiemann reaction. Copyright Taylor & Francis Group, LLC.
- Bhunia, Sankar C.,Patra, Gopal C.,Pal, Sudhir C.
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experimental part
p. 3678 - 3682
(2011/10/09)
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- IBX-mediated one-pot synthesis of benzimidazoles from primary alcohols and arylmethyl bromides
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A variety of primary alcohols are shown to be converted to the corresponding benzimidazoles in one pot by employing IBX and o-phenylenediamine in DMSO at room temperature. o-Iodobenzoic acid is the end product of IBX, which is employed in 1.0 equiv. Arylmethyl bromides are also shown to be converted likewise to benzimidazoles in moderate yields in one pot, albeit at slightly elevated temperatures.
- Moorthy, Jarugu Narasimha,Neogi, Ishita
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supporting information; experimental part
p. 3868 - 3871
(2011/08/06)
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- NOVEL CURCUMIN DERIVATIVE
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The present invention provides a novel compound that is structurally similar to curcumin and has a suppressive effect on Aβ aggregation, a degradative effect on Aβ aggregates, an inhibitory effect on β-secretase, and a protective effect on neurons. The novel compound is a compound represented by the following general formula (Ia) or a salt thereof: wherein R1 represents a 4-hydroxy-3-methoxyphenyl group or the like, and R2 represents a 1H-indol-6-yl group or the like.
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Page/Page column 87
(2009/12/07)
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