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CAS

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519-74-4

2-Benzhydrylpiperidine is a pale brown solid with chemical properties that make it a highly lipophilic molecule, lacking polar functional groups that are typically targeted by metabolic enzymes. This characteristic contributes to its potential applications in the pharmaceutical industry.

519-74-4 Suppliers

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  • 519-74-4 Structure

  • Basic information

    1. Product Name: 2-Benzhydrylpiperidine
    2. Synonyms: 2-DIPHENYLMETHYLPIPERIDINE;2-BENZHYDRYLPIPERIDINE;2-diphenylmethylpiperidine Hcl;2-DIPHENYLMETHYLPIPERIDINE 98%;Desoxypipradrol;Desoxypipradrol 2-DPMP;2-benzhydrylpiperidine hcl;2-Benzhydrylpiperidin
    3. CAS NO:519-74-4
    4. Molecular Formula: C18H21N
    5. Molecular Weight: 251.37
    6. EINECS: 208-276-6
    7. Product Categories: pharmacetical;Amines;Aromatics;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
    8. Mol File: 519-74-4.mol

  • Chemical Properties

    1. Melting Point: 65-66 °C
    2. Boiling Point: 366.3 °C at 760 mmHg
    3. Flash Point: 181.3 °C
    4. Appearance: white crystalline powder
    5. Density: 1.027 g/cm3
    6. Vapor Pressure: 1.48E-05mmHg at 25°C
    7. Refractive Index: 1.567
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. PKA: 10.02±0.10(Predicted)
    11. CAS DataBase Reference: 2-Benzhydrylpiperidine(CAS DataBase Reference)
    12. NIST Chemistry Reference: 2-Benzhydrylpiperidine(519-74-4)
    13. EPA Substance Registry System: 2-Benzhydrylpiperidine(519-74-4)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 519-74-4(Hazardous Substances Data)

519-74-4 Usage

Uses

Used in Pharmaceutical Industry:
2-Benzhydrylpiperidine is used as a norepinephrine-dopamine reuptake inhibitor (NDRI) for its ability to inhibit the reuptake of norepinephrine and dopamine, which are neurotransmitters involved in attention, focus, and mood regulation. This application is particularly relevant for treating attention-deficit hyperactivity disorder (ADHD) and depression, as it can help improve symptoms by increasing the availability of these neurotransmitters in the synaptic cleft.
The unique chemical properties of 2-Benzhydrylpiperidine, such as its high lipophilicity and lack of polar functional groups, make it a promising candidate for further research and development in the pharmaceutical industry, potentially leading to the creation of more effective and targeted treatments for various neurological and psychiatric disorders.

Check Digit Verification of cas no

The CAS Registry Mumber 519-74-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,1 and 9 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 519-74:
(5*5)+(4*1)+(3*9)+(2*7)+(1*4)=74
74 % 10 = 4
So 519-74-4 is a valid CAS Registry Number.
InChI:InChI=1/C18H21N/c1-3-9-15(10-4-1)18(16-11-5-2-6-12-16)17-13-7-8-14-19-17/h1-6,9-12,17-19H,7-8,13-14H2

519-74-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Benzhydrylpiperidine

1.2 Other means of identification

Product number -
Other names Desoxypipradrol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:519-74-4 SDS

519-74-4Relevant articles and documents

Hydrogenation of Pyridines Using a Nitrogen-Modified Titania-Supported Cobalt Catalyst

Chen, Feng,Li, Wu,Sahoo, Basudev,Kreyenschulte, Carsten,Agostini, Giovanni,Lund, Henrik,Junge, Kathrin,Beller, Matthias

supporting information, p. 14488 - 14492 (2018/10/26)

Novel heterogeneous catalysts were prepared by impregnation of titania with a solution of cobalt acetate/melamine and subsequent pyrolysis. The resulting materials show an unusual nitrogen-modified titanium structure through partial implementation of nitrogen into the support. The optimal catalyst displayed good activity and selectivity for challenging pyridine hydrogenation under acid free conditions in water as solvent.