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519016-88-7

N-(3-bromophenyl)-3-chloropropanamide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 519016-88-7 Structure

  • Basic information

    1. Product Name: N-(3-bromophenyl)-3-chloropropanamide
    2. Synonyms: N-(3-bromophenyl)-3-chloropropanamide
    3. CAS NO:519016-88-7
    4. Molecular Formula: C9H9BrClNO
    5. Molecular Weight: 262.53086
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 519016-88-7.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: N-(3-bromophenyl)-3-chloropropanamide(CAS DataBase Reference)
    10. NIST Chemistry Reference: N-(3-bromophenyl)-3-chloropropanamide(519016-88-7)
    11. EPA Substance Registry System: N-(3-bromophenyl)-3-chloropropanamide(519016-88-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 519016-88-7(Hazardous Substances Data)

519016-88-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 519016-88-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,1,9,0,1 and 6 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 519016-88:
(8*5)+(7*1)+(6*9)+(5*0)+(4*1)+(3*6)+(2*8)+(1*8)=147
147 % 10 = 7
So 519016-88-7 is a valid CAS Registry Number.

519016-88-7Relevant articles and documents

Discovery of new potent protein arginine methyltransferase 5 (PRMT5) inhibitors by assembly of key pharmacophores from known inhibitors

Zhu, Kongkai,Song, Jia-Li,Tao, Hong-Rui,Cheng, Zhi-Qiang,Jiang, Cheng-Shi,Zhang, Hua

supporting information, p. 3693 - 3699 (2018/10/24)

Protein arginine methyltransferase 5 (PRMT5) is an epigenetics related enzyme that has been validated as a promising therapeutic target for human cancer. Up to now, two small molecule PRMT5 inhibitors has been put into phase I clinical trial. In the prese

Synthesis and antimalarial activity of N-benzylated (N-arylcarbamoyl)alkylphosphonic acid derivatives

Adeyemi, Christiana M.,Faridoon,Isaacs, Michelle,Mnkandhla, Dumisani,Hoppe, Heinrich C.,Krause, Rui W.M.,Kaye, Perry T.

, p. 6131 - 6138 (2016/12/06)

A series of novel and readily accessible N-benzylated (N-arylcarbamoyl)alkylphosphonate esters and related compounds have been prepared as potential antimalarial agents. Bioassays reveal that some of these compounds exhibit promising activity against Plasmodium falciparum, and exhibit no significant growth inhibition of HeLa cells.

Exploring DOXP-reductoisomerase binding limits using phosphonated N-aryl and N-heteroarylcarboxamides as DXR inhibitors

Bodill, Taryn,Conibear, Anne C.,Mutorwa, Marius K.M.,Goble, Jessica L.,Blatch, Gregory L.,Lobb, Kevin A.,Klein, Rosalyn,Kaye, Perry T.

supporting information, p. 4332 - 4341 (2013/07/27)

DOXP-reductoisomerase (DXR) is a validated target for the development of antimalarial drugs to address the increase in resistant strains of Plasmodium falciparum. Series of aryl- and heteroarylcarbamoylphosphonic acids, their diethyl esters and disodium salts have been prepared as analogues of the potent DXR inhibitor fosmidomycin. The effects of the carboxamide N-substituents and the length of the methylene linker have been explored using in silico docking studies, saturation transfer difference NMR spectroscopy and enzyme inhibition assays using both EcDXR and PfDXR. These studies indicate an optimal linker length of two methylene units and have confirmed the importance of an additional binding pocket in the PfDXR active site. Insights into the constraints of the PfDXR binding site provide additional scope for the rational design of DXR inhibitors with increased ligand-receptor interactions.

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