- Smooth receptor ligand
-
The invention relates to the technical field of biology, particularly to a smooth receptor ligand, and provides a smooth receptor ligand or an isomer prodrug, a solvate and a pharmaceutically acceptable salt thereof, wherein the structural formula of the smooth receptor ligand is A-linker-B, A is an extracellular domain ligand structure, B is a transmembrane domain ligand structure, and Linker isa linear subunit inactive to the smooth receptor. According to the novel double-end small molecule ligand for the smooth receptor, by combining the crystal structure data of the smooth receptor, a linker is introduced into the proper sites of an extracellular domain ligand and a transmembrane domain ligand to obtain brand-new double-end ligand small molecules, so that the interaction between the ligand and the receptor and the biological activity of the ligand are enhanced.
- -
-
Paragraph 0085; 0252; 0254; 0263
(2020/04/01)
-
- Click synthesis and complexation properties of a new unsymmetrical macrocycle bearing 1,4-dioxabenzene and triazole units
-
We report herein synthesis of a new triazole-based unsymmetrical macrocycle through Copper(I) catalyzed Alkyne - Azide Cycloadditon (CuAAC), using a copper(I)-N-heterocyclic carbene complex as catalyst. The obtained macrocycle was characterized by NMR spectroscopy and High Resolution Mass Spectrometry (HRMS). The complexation ability of the macrocycle towards various cations as well as its selectivity for a particular metal-ion was investigated by HRMS experiments.
- ANGHEL, Cǎtǎlin C.,BOGDAN, Elena,CUCUIET, Teodor A.,Cri?an, Andreea,Hǎdade, Niculina D.,MATACHE, Mihaela,POP, Lidia,TEREC, Anamaria
-
p. 567 - 572
(2020/10/06)
-
- A 2- chlorine ethoxy group -2-ethoxy-ethanol preparation method (by machine translation)
-
The invention discloses a preparation method of 2-chloroethoxy-2-ethyoxylethanol. The preparation method comprises the steps: with 2-chloroethoxy and ethylene oxide as raw materials, performing a reaction in the presence of a catalyst to firstly obtain 2-ethyoxylethanol, removing the remaining solvent, namely a reactant 2-chlorohydrin, making the 2-ethyoxylethanol continuously react with the re-added ethylene oxide to obtain a target product 2-chloroethoxy-2-ethyoxylethanol. The preparation method has the advantages of being easy to operate during reaction, mild in system, less in side reactions, high in content and yield of products, and less in pollutants generated during the reaction.
- -
-
Paragraph 0039; 0040
(2017/01/02)
-
- STUDY OF THERMAL CONVERSIONS OF ETHYLENE CHLOROHYDRIN (2-CHLOROETHANOL).
-
Ethylene chlorohydrin (ECH) is a widely used industrial solvent and reagent. When used at temperatures above 100-110 degree , ECH undergoes considerable decomposition. The authors of most publications, concerned with thermal stability of ECH, studied its hydrolysis in alkaline, acidic, and neutral solutions at temperatures up to 100 degree , and also free-radical decomposition of ECH at 430-496 degree in the gase phase. There is no information in the literature on the thermal stability of ECH in the liquid phase in the temperature range 110-150 degree . The purpose of the present work was to determine the principal relationships of thermal decomposition in anhydrous ECH in the liquid phase in the temperature range indicated above.
- Zil'berman,Kolesnikov,Danov,Efremov,Pantina
-
p. 2344 - 2347
(2007/10/02)
-