- A dichloro diethyl ether and 2 - chloroethyl phenoxy ethanol synthesis method
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The invention discloses a dichloro diethyl ether and 2 - chloroethyl phenoxy ethanol synthesis method, which belongs to the field of organic synthesis. The method comprises: the molar ratio of 0.8 - 1.5: 0.3 diethylene glycol and catalyst in a double-mouth flask, and the double-mouth flask are respectively connected with two of the mouth of the funnel and a condenser; the use of a separatory funnel to drip the mixed acid in double-mouth flask, in 130 °C - 170 °C under reaction, during the reaction, the use of condenser to collect condensate; the condensate to the distillation is carried out, to obtain dichloro diethyl ether; double-mouth flask in the remaining liquid to filter, to obtain the 2 - chloroethyl phenoxy ethanol, wherein mixed acid include: mass ratio is 25 - 35:1 of concentrated hydrochloric acid is concentrated sulfuric acid. The embodiment of the invention the synthesis method provided not only can at the same time obtained by synthesizing dichloro diethyl ether and 2 - chloroethyl phenoxy ethanol, but also, the method reaction is simple and controllable, mild reaction conditions, raw materials are safe and easily-obtained, so that the synthesis of the two more safe and controllable, the cost is cheaper.
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Paragraph 0061-0064; 0068; 0069; 0073; 0074; 0079; 0080
(2019/05/16)
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- A 2- chlorine ethoxy group -2-ethoxy-ethanol preparation method (by machine translation)
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The invention discloses a preparation method of 2-chloroethoxy-2-ethyoxylethanol. The preparation method comprises the steps: with 2-chloroethoxy and ethylene oxide as raw materials, performing a reaction in the presence of a catalyst to firstly obtain 2-ethyoxylethanol, removing the remaining solvent, namely a reactant 2-chlorohydrin, making the 2-ethyoxylethanol continuously react with the re-added ethylene oxide to obtain a target product 2-chloroethoxy-2-ethyoxylethanol. The preparation method has the advantages of being easy to operate during reaction, mild in system, less in side reactions, high in content and yield of products, and less in pollutants generated during the reaction.
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Paragraph 0037; 0038
(2017/01/02)
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- Hydrolysis of Nitrite Esters: Putative Intermediates in the Biotransformation of Organic Nitrates
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Study and comparison of the pH-independent hydrolysis of eight alkyl nitrites shows 3-nitroso-1,2-glyceryl dinitrate, a putative intermediate in the biotransformation of glyceryl trinitrate, to be unexpectedly reactive and too labile to be detected as a biotransformation intermediate in aqueous solution, suggesting a role for neighbouring group participation by the β-nitrate group.
- Buckell, Felicity,Hartry, Jeffrey D.,Rajalingam, Umarani,Bennett, Brian M.,Whitney, Ralph A.,Thatcher, Gregory R. J.
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p. 401 - 404
(2007/10/02)
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- Metal-assisted Reactions. Part 17. Ring-opening and Dimerization of Cyclic Ethers by Titanium Halides
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Reaction of TiCl4 or TiBr4 with a variety of cyclic ethers gives, predominantly, products resulting from simple ring-opening or from ring-opening with simultaneous condensation to dimeric species.The variations in yields of these two kinds of products might be correlated qualitatively with an initial formation of the complex TiX4*2E (X = Cl or Br; E = cyclic ether) in which the ethers were held in a cis or trans relationship.Although such a correlation might suggest that TiCl4 but not TiBr4 exerts a template effect on the condensation, stereochemical considerations of the reaction products indicate otherwise.TiCl3 and VCl3 do not give similar results and TiF4 gives no reaction.
- Delaney, Paul A.,Johnstone, Robert A. W.,Entwistle, Ian D.
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p. 1855 - 1860
(2007/10/02)
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- STUDY OF THERMAL CONVERSIONS OF ETHYLENE CHLOROHYDRIN (2-CHLOROETHANOL).
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Ethylene chlorohydrin (ECH) is a widely used industrial solvent and reagent. When used at temperatures above 100-110 degree , ECH undergoes considerable decomposition. The authors of most publications, concerned with thermal stability of ECH, studied its hydrolysis in alkaline, acidic, and neutral solutions at temperatures up to 100 degree , and also free-radical decomposition of ECH at 430-496 degree in the gase phase. There is no information in the literature on the thermal stability of ECH in the liquid phase in the temperature range 110-150 degree . The purpose of the present work was to determine the principal relationships of thermal decomposition in anhydrous ECH in the liquid phase in the temperature range indicated above.
- Zil'berman,Kolesnikov,Danov,Efremov,Pantina
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p. 2344 - 2347
(2007/10/02)
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- Organotin-containing composition for the stabilization of polymers of vinyl chloride
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An organotin-containing composition for the stabilization of polymers or copolymers of vinyl chloride in which there is incorporated a stabilizing amount of an organotin compound containing at least two tin atoms and which is a mercapto, hydroxy or alkoxy substituted ester of a mercapto acid substituted organotin mercapto acid diester.
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- THERMAL CONVERSIONS OF 2,2 prime -DICHLORODIETHYL ETHER.
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When previously purified 2,2 prime -dichlorodiethyl ether was heated at 130-190 degree , it was found to contain ethylene chlorohydrin, 1,2-dichloroethane, 1,4-dioxane, chloroacetaldehyde, ethylene glycol 2-chloroethyl ether, acetaldehyde, vinyl chloride, hydrogen chloride, water, and peroxides. It is shown that thermal decomposition of DCDE is due mainly to formation of peroxides, which decompose into free radicals which initiate the decomposition. Formation of the principal decomposition products during heating of DCDE is suppressed in presence of inhibitors of free-radical reactions.
- Kolesnikov,Danov,Efremov,Zil'berman
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p. 308 - 311
(2007/10/02)
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- Opening of Cyclic Acetals by Trichloro-, Dichloro- and Tribromo-borane
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The rate-determining step in the ring opening of cyclic acetals by trichloroborane to yield α-chloro-ethers is shown to be consistent with the formation of an oxocarbenium ion.Subsequent reduction provides a general route for the conversion of a diol into a hydroxy-ether.Tribromoborane is a more powerful and dichloroborane a less powerful reagent than trichloroborane.
- Bonner, Trevor G.,Lewis, David,Rutter, Keith
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p. 1807 - 1810
(2007/10/02)
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- On the chemistry of etofenamate, a novel antiinflammatory agent from the series of N arylanthranilic acid derivatives
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2-(2-hydroxyethoxy)ethyl-N-(α,α,α-trifluoro-m-toly)anthranilate (etofenamate) was selected as an antiphlogistic agent for percutaneous therapy. Its characteristic alcohol-ether-ester structure brings about an increase in lipophilia and in its ability to penetrate through the intact skin. Furthermore, its oily consistency renders it ideal for pharmaceutical formulation in gels. The physico-chemical material constants, partition coefficients (R(m) values) as a measure for lipophilia, spectra and molecular models of etofenamate are described. Various methods of synthesis of etofenamate and of its intermediates are described. Structural identification is made of by-products simultaneously obtained in the reaction. Pure etofenamate is obtained through repeated molecular distillation. The synthesis is carried out uniformly with protected reaction components and, after splitting off the protective groups, extremely pure etofenamate is obtained.
- Boltze,Kreisfeld
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p. 1300 - 1312
(2007/10/08)
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