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520-85-4

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Ruggieri,Ferrari
p. 5725
(1959)
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NOVEL ESTERS OF MEDROXYPROGESTERONE
The present disclosure relates to novel ester forms of medroxyprogesterone, process for their preparation and pharmaceutical compositions comprising the same. The present disclosure also relates to use of the novel ester forms in hormonal therapies such as, for example, contraception, hormone replacement therapy, endometriosis, etc.
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Paragraph 00055

(2020/12/30)

Water-soluble steroid compounds
Beta-cyclodextrin forms a water-soluble complex or inclusion compound with steroid compounds having a molecular structure smaller than the interior cavity in the doughnut-shaped molecular structure of beta-cyclodextrin. The resulting inclusion compounds can be used for a variety of applications including aqueous topical ophthalmic preparations and topical dermatological ointments.
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(2008/06/13)

Novel 17-esters of 17α-hydroxy gestogens, compositions containing such compounds, processes for their preparation and methods of treatment therewith
This invention relates to novel 17α-esters of gestogens having an antitumour activity and to the preparation thereof. The invention is also concerned with pharmaceutical compositions containing the said compounds, and method of treatment therewith.
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(2008/06/13)

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Chemical Properties

Melting Point: 204-206°C
Boiling Point: 488°Cat760mmHg
Flash Point:263°C
Density: 1.13g/cm³
Solubility:Chloroform (Slightly), Methanol (Slightly)
Storage Temp.:Refrigerator
Vapor Pressure: 5.44E-10mmHg at 25°C
Refractive Index: 1.5000 (estimate)
PKA: 13.03±0.70(Predicted)
Merck: 13,5817
BRN: 2510965
PSA: 54.37000
LogP: 4.08440

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