- Preparation method of palace progesterone
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The invention relates to the technical field of preparation of pharmaceutical active pharmaceutical chemicals, in particular to a preparation method of palace progesterone. To the preparation method, 17 α - hydroxyl progesterone is used as a substrate, and nucleophilic addition reaction is carried out in sequence. An epoxidation reaction, an open-loop addition reaction, an elimination reaction, an esterification reaction and a hydrolysis reaction are adopted to obtain the toecliptin progesterone, and a precious metal catalyst and a carcinogenic solvent are not used in the preparation process simultaneously. ≥ 91%.
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Paragraph 0115; 0117; 0124; 0126; 0131; 0133; 0138-0141
(2021/11/03)
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