- Preparation method of palace progesterone
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The invention relates to the technical field of preparation of pharmaceutical active pharmaceutical chemicals, in particular to a preparation method of palace progesterone. To the preparation method, 17 α - hydroxyl progesterone is used as a substrate, and nucleophilic addition reaction is carried out in sequence. An epoxidation reaction, an open-loop addition reaction, an elimination reaction, an esterification reaction and a hydrolysis reaction are adopted to obtain the toecliptin progesterone, and a precious metal catalyst and a carcinogenic solvent are not used in the preparation process simultaneously. ≥ 91%.
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Paragraph 0115-0116; 0124-0125; 0131-0132
(2021/11/03)
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- Hormone-based nitrogen monoxide donor compounds and use thereof in obstetrics and gynecology
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The invention concerns compounds capable of being fixed on hormone receptors and having a nitrogen monoxide donor group, their use for preventing premature births, increasing cervical-dilatation, for use in hormone substitution therapy as anti-hypertensive drug and their therapeutic use for preparing a medicine for use in obstetrics and gynecology.
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Page/Page column 4-5
(2008/06/13)
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