- Heterocyclic derivatives as well as pharmaceutical compositions and application thereof
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The invention discloses novel heterocyclic derivatives shown in a formula I, a formula II and a formula III, pharmaceutical compositions containing the heterocyclic derivatives and application of the heterocyclic derivatives in preparation of drugs for preventing and/or treating indications related to proton pump inhibition regulation. The heterocyclic derivatives disclosed by the invention are strong in drug effect and long in half-life period, are ideal efficient proton pump inhibitors, and can be used for treating or preventing diseases or diseases needing proton pump inhibition effect regulation, such as ulcer, esophagitis, gastritis, gastroesophageal reflux, helicobacter pylori infection, gastric cancer and the like.
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Paragraph 0145; 0148; 0149
(2021/05/26)
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- Highly selective sp3 C-N bond activation of tertiary anilines modulated by steric and thermodynamic factors
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A highly selective sp3 C-N cleavage of tertiary anilines was achieved using the TBN/TEMPO catalyst system. When N,N-diaklylanilines (alkyl, benzyl) were employed, the N-CH3 bond was selectively cleaved via radical C-H activation. Moreover, when the allyl group was installed, totally reverse selectivity was observed. It is worth noting that the solvent effect is also crucial to obtain high reaction efficiency and selectivity.
- Jia, Xiaodong,Li, Pengfei,Shao, Yu,Yuan, Yu,Ji, Honghe,Hou, Wentao,Liu, Xiaofei,Zhang, Xuewen
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supporting information
p. 5568 - 5574
(2017/12/06)
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- Gold catalysis coupled with visible light stimulation: Syntheses of functionalized indoles
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A judicious combination of Au-catalysis and synergistic visible-light stimulation formulates an exceptionally simple and mild reaction system capable of directly coupling anilines and alkynes to form multifunctionalized indoles.
- Cai, Shunyou,Yang, Kai,Wang, David Zhigang
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supporting information
p. 2606 - 2609
(2014/06/09)
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- Nitropyridines 11.* recyclization of quaternary nitropyridinium salts into substituted nitroanilines
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Substituted nitroanilines have been obtained by the recyclization of nitropyridinium quaternary salts under the action of bases.
- Garkushenko,Poendaev,Vorontsova,Sagitullina
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experimental part
p. 470 - 481
(2012/01/13)
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- SYNTHESIS OF INDOLES FROM PYRIDINIUM SALTS 5. SECONDARY AMINES IN THE REACTION OF 3-NITROPYRIDINIUM SALTS WITH ACETONE
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The use of secondary amines in the reaction of 3-nitropyridinium salts with acetone makes it possible to isolate stable intermediates in the formation of indoles - (o-N,N-dialkylaminobenzyl)ketones - and to observe new reaction pathways - the formation of bisindolylpropanes and p-nitroanilines.
- Yurkovskaya, M. A.,Afanas'ev, A. Z.,Chertkov, V. A.,Bundel', Yu. G.
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p. 1000 - 1008
(2007/10/02)
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