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523988-37-6

1-Azabicyclo[3.2.0]heptane-2-carboxylicacid,7-oxo-,methylester,(2R,5S)-(9CI) is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1-Azabicyclo[3.2.0]heptane-2-carboxylicacid,7-oxo-,methylester,(2R,5S)-(9CI)

    Cas No: 523988-37-6

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  • 523988-37-6 Structure

  • Basic information

    1. Product Name: 1-Azabicyclo[3.2.0]heptane-2-carboxylicacid,7-oxo-,methylester,(2R,5S)-(9CI)
    2. Synonyms: 1-Azabicyclo[3.2.0]heptane-2-carboxylicacid,7-oxo-,methylester,(2R,5S)-(9CI)
    3. CAS NO:523988-37-6
    4. Molecular Formula: C8H11NO3
    5. Molecular Weight: 169.18
    6. EINECS: N/A
    7. Product Categories: PYRROLE;GLYCINESCAFFOLD
    8. Mol File: 523988-37-6.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 1-Azabicyclo[3.2.0]heptane-2-carboxylicacid,7-oxo-,methylester,(2R,5S)-(9CI)(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1-Azabicyclo[3.2.0]heptane-2-carboxylicacid,7-oxo-,methylester,(2R,5S)-(9CI)(523988-37-6)
    11. EPA Substance Registry System: 1-Azabicyclo[3.2.0]heptane-2-carboxylicacid,7-oxo-,methylester,(2R,5S)-(9CI)(523988-37-6)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 523988-37-6(Hazardous Substances Data)

523988-37-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 523988-37-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,2,3,9,8 and 8 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 523988-37:
(8*5)+(7*2)+(6*3)+(5*9)+(4*8)+(3*8)+(2*3)+(1*7)=186
186 % 10 = 6
So 523988-37-6 is a valid CAS Registry Number.

523988-37-6Downstream Products

523988-37-6Relevant articles and documents

Enantiopure synthesis of all four stereoisomers of carbapenam-3-carboxylic acid methyl ester

Avenoza, Alberto,Barriobero, Jose I.,Busto, Jesus H.,Peregrina, Jesus M.

, p. 2889 - 2894 (2007/10/03)

The retro-Dieckmann reaction has been used as a stereodivergent synthetic tool on N-Boc-7-azabicyclo[2.2.1]heptan-2-one-1-carboxylic acid methyl ester to obtain enantiopure trans- and cis-5-(carboxymethyl)pyrrolidine-2-carboxylic acid methyl esters. These disubstituted pyrrolidines have been used as starting materials to develop concise and straightforward syntheses of all four stereoisomers of carbapenam-3-carboxylic acid methyl esters. In this way, we have confirmed unequivocally the stereochemistry of two carbapenams isolated from strains of Serratia and Erwinia species.

Convenient syntheses of (3S,5S)-carbapenam-3-carboxylates and their biosynthetic relevance

Bycroft, Barrie W.,Chhabra, Siri Ram,Kellam, Barrie,Smith, Paul

, p. 973 - 976 (2007/10/03)

Starting from readily available glutamate derivatives, facile stereoselective syntheses of (3S,5S)-carbapenam-3-carboxylates have been developed. Their significance in confirming the absolute configuration of the natural material is discussed.

Diastereoselective synthesis of 3,5-trans-(+)-(3R,5R)-3-carbomethoxycarbapenam from 3-hydroxypyridine: Questioning the stereochemical assignment of the natural product

Tanaka, Hideyuki,Sakagami, Hideki,Ogasawara, Kunio

, p. 93 - 96 (2007/10/03)

An enantio- and diastereoselective synthesis of the methyl ester of 3,5-trans-(3R,5R)-carbapenam-3-carboxylic acid from 3-hydroxypyridine via (2R,5S)-trans-5-acetoxy-2-allylpiperidine has been achieved by employing the piperidine-pyrrolidine ring-contract

Azabicyclo[3.2.0]heptan-7-ones (carbapenams) from pyrrole

Gilchrist, Thomas L.,Lemos, Americo,Ottaway, Carol J.

, p. 3005 - 3012 (2007/10/03)

The azabicyclo[3.2.0]heptan-7-ones 4, 10, 16 and 24 have been prepared from pyrrole. The same general approach has been used for all these derivatives; namely, substitution of pyrrole at the 2- and 5-carbon atoms, catalytic hydrogenation to produce pyrrolidine-2-acetic acid derivatives, and cyclisation using tris(1,3-dihydro-2-oxobenzoxazol-3-yl)phosphine oxide 6. The catalytic hydrogenation of 2,5-disubstituted pyrroles gives only the corresponding cis-2,5-disubstituted pyrrolidines. The hydrogenation proceeds more easily when the nitrogen atom bears a tert-butoxycarbonyl substituent. The N-tert-butoxycarbonylpyrroles 8 and 21 bearing an α-substituent in the acetate side chain were hydrogenated with a high degree of facial stereoselectivity. This allowed the 6-phthalimidoazabicyclo-[3.2.0]heptan-7-one 24 to be isolated as a single diastereoisomer. The X-ray crystal structure of a precursor, the triester, 22a, has been obtained.

SYNTHESIS OF 3,5-TRANS-3-METHOXYCARBONYL-1-CARBAPENAM FROM METHYL (+/-)-PYROGLUTAMATE

Nagasaka, Tatsuo,Tsukada, Atsuhiko,Hamaguchi, Fumiko

, p. 2015 - 2022 (2007/10/02)

Synthesis of 3,5-trans-3-methoxycarbonyl-1-carbapenam in six steps from methyl (+/-)-pyroglutamate is described.

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