5267-67-4

Basic information

• Product Name: N-[3-(1,3-benzothiazol-2-yl)phenyl]-3,4-difluorobenzamide
• CAS NO: 5267-67-4
• Molecular Formula: C₁₆H₁₇NO
• Molecular Weight: 366.3839
• Mol File: 5267-67-4.mol

Chemical Properties

• Density: 1.415g/cm³
• Refractive Index: 1.697
• CAS DataBase Reference: N-[3-(1,3-benzothiazol-2-yl)phenyl]-3,4-difluorobenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[3-(1,3-benzothiazol-2-yl)phenyl]-3,4-difluorobenzamide(5267-67-4)
• EPA Substance Registry System: N-[3-(1,3-benzothiazol-2-yl)phenyl]-3,4-difluorobenzamide(5267-67-4)

Safety Data

• Hazardous Substances Data: 5267-67-4(Hazardous Substances Data)

Upstream product

• 51-64-9 dexamfetamine 
• 98-88-4 benzoyl chloride 
• 3182-95-4 L-Phenylalaninol 
• 59903-80-9 (S)-3-Methyl-2-(1-methyl-2-phenyl-ethylamino)-butyric acid ethyl ester 
• 59903-79-6 (S)-2-(1-Methyl-2-phenyl-ethylamino)-propionic acid tert-butyl ester 
• 87670-06-2 3-Methyl-2-[(E)-1-methyl-2-phenyl-ethylimino]-butyric acid ethyl ester 
• 59903-65-0 (S)-2-[1-Methyl-2-phenyl-eth-(Z)-ylideneamino]-propionic acid ethyl ester 
• 87670-05-1 2-[(E)-1-Methyl-2-phenyl-ethylimino]-propionic acid ethyl ester 
• 87669-78-1 C₁₄H₂₀ClNO₂ 
• 59903-66-1 (S)-2-[1-Methyl-2-phenyl-eth-(Z)-ylideneamino]-propionic acid tert-butyl ester 
• 87670-14-2 3-Methyl-2-[(E)-1-methyl-2-phenyl-ethylimino]-butyric acid tert-butyl ester 
• 87669-90-7 C₁₆H₂₄ClNO₂ 
• 87669-77-0 (S)-3-Methyl-2-(1-methyl-2-phenyl-ethylamino)-butyric acid tert-butyl ester 
• 59903-67-2 (S)-3-Methyl-2-[1-methyl-2-phenyl-eth-(Z)-ylideneamino]-butyric acid ethyl ester 

Relevant articles and documents

Ring opening of pymisyl-protected aziridines with organocuprates

The pyrimidine-2-sulfonyl (pymisyl) group is introduced as a new protecting group that can be used to activate aziridines towards ring opening. It is readily introduced and removed under mild conditions. Regioselective ring opening of pymisyl-protected 2-methyl-aziridine with organocuprates gives the corresponding sulfonamides in high yields, and the pymisyl group can subsequently be removed upon treatment with a thiolate. The versatility of this new nitrogen protecting group is illustrated with a new synthesis of Selegiline, a monoamine oxidase-B inhibitor marketed for the treatment of Parkinson's disease. Easy on'easy off: The pymisyl group is introduced as a new protecting group for the activation of aziridines towards ring opening with organocuprates (see scheme). It is readily removed under very mild conditions with thiolates. The versatility of the approach is illustrated in a new synthesis of Selegiline, a drug marketed for the treatment of Parkinson's disease.

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