51-64-9

Basic information

• Product Name: D-AMPHETAMINE HYDROCHLORIDE
• Synonyms: DEXTRO-AMPHETAMINE;D-AMPHETAMINE;D-AMPHETAMINE HYDROCHLORIDE;(aS)-a-Methyl-benzeneethanamine;d-a-Methylphenethylamine;DELTA-AMPHETAMINE;C07884;S(+)-Amphetamine, 1.0 mg/mL
• CAS NO: 51-64-9
• Molecular Formula: C₉H₁₃N
• Molecular Weight: 171.67
• EINECS: 200-112-1
• Product Categories: Amines;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 51-64-9.mol
• Article Data: 111

Chemical Properties

• Melting Point: 25°C
• Boiling Point: 208.93°C (estimate)
• Flash Point: 9℃
• Appearance: Colorless, oily liquid.
• Density: 0.9354 (estimate)
• Refractive Index: 1.5087 (estimate)
• Storage Temp.: ?20°C
• PKA: pKa 9.90 (Uncertain)
• CAS DataBase Reference: D-AMPHETAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: D-AMPHETAMINE HYDROCHLORIDE(51-64-9)
• EPA Substance Registry System: D-AMPHETAMINE HYDROCHLORIDE(51-64-9)

Safety Data

• Hazard Codes: F,T
• Statements: 11-23/24/25-39/23/24/25
• Safety Statements: 16-36/37-45
• RIDADR: 3249
• WGK Germany: 1
• HazardClass: 6.1(a)
• PackingGroup: II
• Hazardous Substances Data: 51-64-9(Hazardous Substances Data)

Usage

Uses

CNS stimulant; anorexic. More active isomer of Amphetamine. Induces release of catecholamines and serotonin by displacing the monoamines from their vesicular storage sites; blocks catecholamine reuptake. Controlled substance (stimulant)

Definition

ChEBI: A 1-phenylpropan-2-amine that has S configuration.

Brand name

Dexampex (Teva); Dexedrine (GlaxoSmithKline); Dextrostat (Shire); Ferndex (Ferndale);Adiparthrol;Afatin;Amfe-dyn;Amphaetex;Bipheramine;Curban;D-amfetasul;Dexadrine;Dexamed;Dexedrina;Dexten;Dextro-profetamine;Drinamyl;Durophet-m;Maxiton;Mephadexamine-r;Mephadexamin-r;Obetrol;Obotan;Proptan;Robese;Simpamina d;Steladex;Stil-2;Synatan.

World Health Organization (WHO)

Schedule II of the 1971 Convention on Psychotropic Substances. See WHO comment for amfetamine. (Reference: (UNCPS2) United Nations Convention on Psychotropic Substances (II), , , 1971)

Safety Profile

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental reproductive effects. Chronic exposure causes central nervous system damage and blood-pressure effects. When heated to decomposition it emits toxic NOx. See other amphetamine entries.

InChI:InChI=1/C9H13N/c1-8(10)7-9-5-3-2-4-6-9/h2-6,8H,7,10H2,1H3/t8-/m0/s1

Upstream product

• 17019-26-0 (E)-2-(hydroxyimino)-1-phenylpropan-1-one 
• 5171-99-3 (1-phenylpropan-2-ylidene)hydrazine 
• 77287-34-4 formamide 
• 103-79-7 1-phenyl-acetone 
• 17322-34-8 (2-nitropropyl)benzene 
• 123-39-7 N-Methylformamide 
• 593-51-1 methylamine hydrochloride 
• 141-78-6 ethyl acetate 
• 60-15-1 2-amino-1-phenylpropane 
• 1384127-07-4 N-octanoyl dimethyl glycine trifluoroethyl ester 
• 87227-77-8 bishydrochloride salt of cis-1,4-diamino-but-2-ene 
• 591-51-5 phenyllithium 
• 1527-16-8 2-phenylthiophenylacetonitrile 
• 100-52-7 benzaldehyde 

Downstream Products

• 4663-88-1 ((S)-1-methyl-2-phenyl-ethyl)-carbamic acid-(2-hydroxy-ethyl ester) 
• 105340-05-4 1-(1-methyl-2-phenyl-ethyl)-imidazolidin-2-one 
• 139-68-4 nicotinic acid-((S)-1-methyl-2-phenyl-ethylamide) 
• 15855-02-4 N-α-Methylphenethyl-n-pyridincarboxamid 
• 139-68-4 (+/-)-nicotinic acid-(1-methyl-2-phenyl-ethylamide) 
• 51-64-9 dexamfetamine 
• 156-34-3 l-amphetamine 
• 16119-46-3 1-(1-methyl-2-phenyl-ethyl)-5-phenyl-imidazolidine-2,4-dione 
• 54704-34-6 L-1-methyl-2-cyclohexylethylamine 
• 26343-76-0 (S)-(-)-2-ethoxycarbonylamino-1-phenylpropane 
• 27822-59-9 DL-α-Methyl-phenethylcarbamidsaeureethylester 
• 102758-29-2 N,N'-bis-((S)-1-methyl-2-phenyl-ethyl)-succinamide 
• 57760-14-2 (S)-(-)-N-acetyl-α-methylphenylethylamine 
• 101584-18-3 phenoxyacetic acid-((S)-1-methyl-2-phenyl-ethylamide) 

Relevant articles and documents

Direct Access to Primary Amines from Alkenes by Selective Metal-Free Hydroamination

Direct and selective synthesis of primary amines from easily available precursors is attractive yet challenging. Herein, we report the rapid synthesis of primary amines from alkenes via metal-free regioselective hydroamination at room temperature. Ammonium carbonate was used as ammonia surrogate for the first time, allowing for efficient conversion of terminal and internal alkenes into linear, α-branched, and α-tertiary primary amines under mild conditions. This method provides a straightforward and powerful approach to a wide spectrum of advanced, highly functionalized primary amines which are of particular interest in pharmaceutical chemistry and other areas.

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