52858-57-8

Basic information

• Product Name: THPA
• Synonyms: 2-Propenoic acid tetrahydro-2H-pyran-2-yl ester;2-Tetrahydropyranyl acrylate;2-Tetrahydropyranyl acrylate contains =97%
• CAS NO: 52858-57-8
• Molecular Formula: C8H12O3
• Molecular Weight: 156.17908
• Mol File: 52858-57-8.mol

Chemical Properties

• Flash Point: 80℃
• Appearance: /
• Density: 1.05 g/mL at 25 °C(lit.)
• Refractive Index: n20/D1.457
• Storage Temp.: 2-8°C
• CAS DataBase Reference: THPA(CAS DataBase Reference)
• NIST Chemistry Reference: THPA(52858-57-8)
• EPA Substance Registry System: THPA(52858-57-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• RIDADR: NA 1993 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 52858-57-8(Hazardous Substances Data)

Usage

Uses

Used in Photoresist Applications:
THPA is used as a monomer in the formation of photoresists, which are essential in the semiconductor industry for the production of microelectronic components. Its use in photoresists allows for the creation of high-resolution patterns on silicon wafers during the manufacturing process.
Used in Coatings Industry:
THPA is used as a comonomer in the coatings industry to improve the adhesion, flexibility, and durability of the final product. Its compatibility with various monomers and resins makes it a valuable addition to the formulation of coatings, inks, and adhesives.
Used as a Protected Acrylic Acid:
THPA can also be used as a protected acrylic acid, which is beneficial in various chemical reactions and processes. The protection of the acrylic acid group allows for controlled reactions and can improve the overall efficiency of the process.

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 92-84-2 10H-phenothiazine 
• 79-10-7 acrylic acid 

Relevant articles and documents

Microfluidically fabricated pH-responsive anionic amphiphilic microgels for drug release

Amphiphilic microgels of different composition based on the hydrophilic, pH-responsive acrylic acid (AA) and the hydrophobic, non-ionic n-butyl acrylate (BuA) were synthesised using a lab-on-a-chip device. Hydrophobic droplets were generated via a microfluidic platform that contained a protected form of AA, BuA, the hydrophobic crosslinker, ethylene glycol dimethacrylate (EGDMA), and a free radical initiator in an organic solvent. These hydrophobic droplets were photopolymerised within the microfluidic channels and subsequently hydrolysed, enabling an integrated platform for the rapid, automated, and in situ production of anionic amphiphilic microgels. The amphiphilic microgels did not feature the conventional core-shell structure but were instead based on random amphiphilic copolymers of AA and BuA and hydrophobic crosslinks. Due to their amphiphilic nature they were able to encapsulate and deliver both hydrophobic and hydrophilic moieties. The model drug delivery and the swelling ability of the microgels were influenced by the pH of the surrounding aqueous solution and the hydrophobic content of the microgels.

Tailoring pH-responsive acrylic acid microgels with hydrophobic crosslinks for drug release

Amphiphilic microgels based on the hydrophilic acrylic acid (AA) and hydrophobic crosslinks of different compositions were synthesised using a lab-on-a-chip device. The microgels were formed by polymerising hydrophobic droplets. The droplets were generated via a microfluidic platform and contained a protected form of AA, a hydrophobic crosslinker (ethylene glycol dimethacrylate, EGDMA) and a free radical initiator in an organic solvent. Following photopolymerisation and subsequent hydrolysis, AA based microgels of amphiphilic nature were produced and it was demonstrated that they can successfully deliver both hydrophilic as well as hydrophobic moieties. The model drug delivery and the swelling ability of the microgels were influenced by the pH of the aqueous solution as well as the crosslinking density and hydrophobic content of the microgels.

Catalyzed process for reacting carboxylic acids with vinyl ethers

The present invention relates to a process for the reaction of carboxylic acids with vinyl ethers using a non-polymeric pyridine hydrochloride and/or polymeric vinylpyridine hydrochloride as a catalyst.