529-89-5

Basic information

• Product Name: 2,4-DIHYDROXY-3-FORMYLQUINOLINE
• Synonyms: NORDICTAMNAL;2,4-DIHYDROXY-3-FORMYLQUINOLINE;2,4-DIHYDROXY-3-QUINOLINECARBOXALDEHYDE;3-FORMYL-2,4-DIHYDROXYQUINOLINE;. Nordictamnal 2,4-Dihydroxy-3-quinolinecarboxaldehyde 3-Formyl-2,4-dihydroxyquinoline;3-Quinolinecarboxaldehyde, 2, 4-dihydroxy-;4-Hydroxy-2-oxo-1,2-dihydro-quinoline-3-carbaldehyde
• CAS NO: 529-89-5
• Molecular Formula: C₁₀H₇NO₃
• Molecular Weight: 189.17
• Mol File: 529-89-5.mol

Chemical Properties

• Boiling Point: 393.9 °C at 760 mmHg
• Flash Point: 192 °C
• Appearance: /
• Density: 1.509 g/cm³
• Vapor Pressure: 2.87E-08mmHg at 25°C
• Refractive Index: 1.74
• CAS DataBase Reference: 2,4-DIHYDROXY-3-FORMYLQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DIHYDROXY-3-FORMYLQUINOLINE(529-89-5)
• EPA Substance Registry System: 2,4-DIHYDROXY-3-FORMYLQUINOLINE(529-89-5)

Safety Data

• Hazardous Substances Data: 529-89-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,4-Dihydroxy-3-formylquinoline is used as a precursor in the synthesis of bioactive molecules for various pharmaceutical applications. Its ability to act as an intermediate in the biosynthesis of yohimbine, a natural product with potential therapeutic effects, makes it a valuable compound in the development of new drugs.
Used in Organic Synthesis:
2,4-Dihydroxy-3-formylquinoline is used as an intermediate in the synthesis of a variety of organic compounds. Its unique chemical structure allows for the creation of diverse molecules with potential applications in various industries.
Used in Antioxidant Applications:
2,4-Dihydroxy-3-formylquinoline is used as an antioxidant due to its ability to neutralize free radicals and protect cells from oxidative damage. Its antioxidant properties have shown promise in studies for potential therapeutic effects, making it a valuable compound in the development of treatments for various diseases and conditions related to oxidative stress.
Used in Research and Development:
2,4-Dihydroxy-3-formylquinoline is used in research and development for its potential applications in various fields, including pharmaceuticals, organic synthesis, and therapeutics. Its unique properties and potential uses make it an important compound for further investigation and exploration.

InChI:InChI=1/C10H7NO3/c12-5-7-9(13)6-3-1-2-4-8(6)11-10(7)14/h1-5,12H,(H,11,14)/b7-5-

Upstream product

• 70254-44-3 2,4-dihydroxyquinoline 
• 67-66-3 chloroform 
• 70254-43-2 4-Hydroxy-2-quinolone 
• 62-53-3 aniline 
• 148586-97-4 3-[1-(2,6-Dimethyl-phenylamino)-meth-(Z)-ylidene]-1H-quinoline-2,4-dione 
• 59856-27-8 3-[(phenylamino)methylene]quinoline-2,4(1H,3H)-dione 

Downstream Products

• 1190084-56-0 C₁₇H₁₄N₂O₂ 
• 1190084-54-8 C₁₆H₁₁N₃O₄ 
• 1190084-53-7 C₁₆H₁₁N₃O₄ 
• 55567-59-4 3-phenyliminomethyl-4-hydroxy-2-quinolone 
• 1190084-55-9 C₁₇H₁₄N₂O₂ 
• 81115-80-2 3-anilino-2,3-dihydrofuro<3,2-c>quinolin-4(5H)-one 
• 1873-59-2 4-hydroxy-3-methyl-2-quinolone 
• 55567-59-4 3-phenyliminomethyl-4-hydroxy-2-quinolone 

Relevant articles and documents

Synthesis and colon anticancer activity of some novel thiazole/-2-quinolone derivatives

We direct for the synthesis of 1,6,7-trisubstituted-4-phenylthiazol-2(3H)-ylidene)hydrazono)methyl)quinolin-2-one derivatives by the reaction of corresponding thiosemicarbazone derived by 2-quinolone derivatives with 2-bromoacetophenones in presence of triethylamine at room temperature. The mechanism of the formed products was discussed. The structure of the obtained products was fully characterized using different spectral techniques including infrared (IR), nuclear magnetic resonance (NMR), and mass spectrometry (MS) together with elemental analyses. The new synthesized compounds showed a moderate colon anticancer activity.

Synthesis of 4-hydroxy-3-formylideneamino-lH/methyl/phenylquinolin-2-ones

An efficient method for the synthesis of 4-hydroxy-3-formylideneamino-l H/methyl/phenylquinolin-2-ones by the condensation of corresponding 4-hydroxy-3-formyl-l///methyl/phenylquinolin-2-one with substituted anilines/aliphatic primary amines is reported. The carboxaldehyde in turn is prepared starting either from substituted anilines or benzoic acid. The structures of compounds are established by the elemental analysis and spectral data.

Azomethine derivatives as UV light absorbers

The present invention provides a UV light absorber comprising an azomethine compound represented by the formula: [wherein R1 is a hydrogen atom, or a straight- or branched-chain alkyl group having 1 to 4 carbon atoms; and R2 and R3 independently represent a hydrogen atom, a carboxyl group, a halogen atom, an alkoxy group having 1 to 4 carbon atoms, a straight- or branched-chain alkyl group having 1 to 12 carbon atoms or an alkoxycarbonyl group having 2 to 5 carbon atoms] as an active ingredient.

Nucleophilic Chlorination of 3-Formyl-4-hydroxy-quinolin-2(1H)-ones

Chlorination of 1-substituted 3-formyl-4-hydroxy-2-quinolones (1a, b) with phosphorylchloride leads to 4-chloro-3-dichloromethylquinolones (2), which can be hydrolyzed to 4-chloro-3-formylquinolones (4).From the anilinomethylene quinolinediones (3), at lo