53422-20-1

Basic information

• Product Name: 4-Chloro-1-naphthol acetate
• Synonyms: 4-Chloro-1-naphthol acetate
• CAS NO: 53422-20-1
• Molecular Formula: C₁₂H₉ClO₂
• Molecular Weight: 220.65
• Mol File: 53422-20-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Chloro-1-naphthol acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-1-naphthol acetate(53422-20-1)
• EPA Substance Registry System: 4-Chloro-1-naphthol acetate(53422-20-1)

Safety Data

• Hazardous Substances Data: 53422-20-1(Hazardous Substances Data)

Upstream product

• 604-44-4 4-chloronaphthalen-1-ol 
• 10387-40-3 potassium thioacetate 

Downstream Products

• 530740-47-7 1-(4-chloro-1-hydroxy-2-naphthyl)ethanone 
• 127-08-2 potassium acetate 
• 604-44-4 4-chloronaphthalen-1-ol 
• 60-35-5 acetamide 

Relevant articles and documents

Copper-Catalyzed Acetylation of Electron-Rich Phenols and Anilines

An approach has been developed for the copper-catalyzed acetylation of phenols and anilines with potassium thioacetate as an acetylating reagent. Although only electron-rich phenols and anilines are compatible with this protocol, the reaction can provide moderate to high yields under mild conditions. Compared with other acetylating reagents, the current reagent has certain advantages, such as its low cost, easy availability, stability, insensitivity to water or air, and ease of storage.

Method for synthesizing phenyl acetate derivatives

The invention discloses a method for synthesizing phenyl acetate derivatives. The method of the invention comprises the following steps: 1, adding a phenol derivative, potassium thioacetate, copper acetate and acetonitrile to a reaction tube, and tightening the bottle stopper of the reaction tube, and magnetically stirring at 80 DEG C and reacting for 4 h; and 2, extracting with ethyl acetate, mixing organic phases, removing most of the solvent by reduced pressure distillation, and carrying out column chromatography separation and purification on residual mixed liquor by using petroleum etherand ethyl acetate at the volume ratio of 10:1 as a leacheate so as to obtain a target product. By using a phenol derivative as the raw material and using stable potassium thioacetate, which is cheap and easily available and is easy to operate, as an acetylation reagent, a series of phenyl acetate derivatives are efficiently synthesized, and the yield is considerable.