530740-47-7

Basic information

• Product Name: 1-(4-CHLORO-1-HYDROXY-NAPHTHALEN-2-YL)-ETHANONE
• Synonyms: 2-ACETYL-4-CHLORO-1-HYDROXYNAPHTHALENE;1-(4-CHLORO-1-HYDROXY-NAPHTHALEN-2-YL)-ETHANONE
• CAS NO: 530740-47-7
• Molecular Formula: C₁₂H₉ClO₂
• Molecular Weight: 220.65
• Mol File: 530740-47-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 121 °C(Solv: ethanol (64-17-5))
• Boiling Point: 380.3 °C at 760 mmHg
• Flash Point: 183.8 °C
• Appearance: /
• Density: 1.333 g/cm³
• Storage Temp.: 2-8°C
• PKA: 7.44±0.50(Predicted)
• CAS DataBase Reference: 1-(4-CHLORO-1-HYDROXY-NAPHTHALEN-2-YL)-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-CHLORO-1-HYDROXY-NAPHTHALEN-2-YL)-ETHANONE(530740-47-7)
• EPA Substance Registry System: 1-(4-CHLORO-1-HYDROXY-NAPHTHALEN-2-YL)-ETHANONE(530740-47-7)

Safety Data

• Hazardous Substances Data: 530740-47-7(Hazardous Substances Data)

Usage

General Description

1-(4-Chloro-1-hydroxy-naphthalen-2-yl)-ethanone is a chemical compound with a complex structure, consisting of various organic components. As the name indicates, it contains components like Chloro, Hydroxy, Napthalen, and Ethanone. 1-(4-CHLORO-1-HYDROXY-NAPHTHALEN-2-YL)-ETHANONE's presence of a Chloro group indicates it has elements of chlorine in its structure. The compound also contains a hydroxide group (OH) making it a type of hydroxy compound. Naphthalene is a polycyclic aromatic hydrocarbon present in the compound, which indicates it could be derived from crude oil or coal tar. The presence of Ethanone suggests a ketone group, indicating it potentially has characteristics of ketones. Its specific purposes, uses, and properties can vary significantly depending on context, requiring further specific research.

Upstream product

• 36441-29-9 14-phenyl-14H-dibenzo[a.j]xanthene 
• 860538-80-3 bis-(3-acetyl-4-hydroxy-[1]naphthyl)-sulfide 
• 64-19-7 acetic acid 
• 604-44-4 4-chloronaphthalen-1-ol 
• 75-36-5 acetyl chloride 
• 7791-25-5 sulfuryl dichloride 
• 60-29-7 diethyl ether 
• 711-79-5 1-hydroxy-2-acetonaphthone 
• 53422-20-1 4-chloronaphthalen-1-yl acetate 
• 71-43-2 benzene 

Downstream Products

• 1312683-36-5 N-{1-[4-chloro-1-(3-fluorophenyl)-2-naphthyl]ethyl}-9H-purin-6-amine 
• 1312685-87-2 1-[4-chloro-1-(3-fluorophenyl)-2-naphthyl]ethanamine 
• 1312685-86-1 1-[4-chloro-1-(3-fluorophenyl)-2-naphthyl]ethanone 
• 1312683-33-2 1-{4-chloro-2-[1-(9H-purin-6-ylamino)ethyl]-1-naphthyl}piperidin-4-ol 
• 1312685-85-0 1-[2-(1-aminoethyl)-4-chloro-1-naphthyl]piperidin-4-ol 
• 1312685-84-9 1-[4-chloro-1-(4-hydroxypiperidin-1-yl)-2-naphthyl]ethanone 
• 1312685-83-8 2-acetyl-4-chloro-1-naphthyl trifluoromethanesulfonate 

Relevant articles and documents

SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS

The present invention provides fused aryl and heteroaryl derivatives of Formula I that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases

Titanium(IV) chloride-mediated ortho-acylation of phenols and naphthols

The use of titanium(IV) chloride as a Lewis acid for direct ortho-acylation of phenols and naphthols proves to be a convenient, more general and direct route to various hydroxyaryl ketones. The route is regioselective, leading to ortho C-acylated products in satisfactory to high yields in most cases.