541550-00-9

Basic information

• Product Name: 4-METHOXY-3-(TRIFLUOROMETHYL)PHENACYL BROMID
• Synonyms: 4-METHOXY-3-(TRIFLUOROMETHYL)PHENACYL BROMID;2-Bromo-4'-methoxy-3'-(trifluoromethoxy)acetophenone;2-Bromo-4'-methoxy-3'-(trifluoromethyl)acetophenone, 2-Bromo-1-[4-methoxy-3-(trifluoromethyl)phenyl]ethan-1-one, 5-(Bromoacetyl)-2-methoxybenzotrifluoride, 4-(Bromoacetyl)-2-(trifluoromethyl)anisole;2-Bromo-4'-methoxy-3'-(trifluoromethyl)acetophenone, 2-Bromo-1-[4-methoxy-3-(trifluoromethyl)phenyl]ethan-1-one, 5-(Bromoacetyl)-2-methoxybenzotrifluoride, 4-(Bromoacetyl)-2-(trifluo;4-Methoxy-3-(trifluoromethyl)phenacylbromide97%
• CAS NO: 541550-00-9
• Molecular Formula: C₁₀H₈BrF₃O₂
• Molecular Weight: 297.0685296
• Mol File: 541550-00-9.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-METHOXY-3-(TRIFLUOROMETHYL)PHENACYL BROMID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHOXY-3-(TRIFLUOROMETHYL)PHENACYL BROMID(541550-00-9)
• EPA Substance Registry System: 4-METHOXY-3-(TRIFLUOROMETHYL)PHENACYL BROMID(541550-00-9)

Safety Data

• Hazardous Substances Data: 541550-00-9(Hazardous Substances Data)

Upstream product

• 149105-10-2 1-[4-Methoxy-3-(trifluoromethyl)phenyl]ethanone 

Downstream Products

• 942399-44-2 2-acetamido-2-[2-(4-methoxy-3-trifluoromethylphenyl)-2-oxoethyl]malonic acid diethyl ester 

Relevant articles and documents

2-ACYLAMINOTHIAZOLE DERIVATIVE AND SALT THEREOF

[Problem] A compound which is useful as an active ingredient of a pharmaceutical composition for treating storage dysfunctions, voiding dysfunctions, and lower urinary tract diseases is provided. [Means for Solution] The present inventors have found that a thiazole derivative having pyrazine-2-carbonylamino substituted at the 2-position is an excellent muscarinic M 3 receptor positive allosteric modulator, and is useful as an agent for preventing and/or treating bladder or urinary tract diseases, related to bladder contraction by a muscarinic M 3 receptor, thereby completing the present invention. The 2-acylaminothiazole derivative or a salt thereof of the present invention can be used as an agent for preventing and/or treating bladder or urinary tract diseases, related to bladder contraction by a muscarinic M 3 receptor, for example, voiding dysfunctions such as underactive bladder.

AMINE COMPOUND AND PHARMACEUTICAL USE THEREOF

Provided is a novel amine compound represented by the following formula (I) having a superior peripheral blood lymphocyte decreasing action and superior in the immunosuppressive action, rejection suppressive action and the like, which shows decreased side effects of, for example, bradycardia and the like, or a pharmaceutically acceptable acid addition salt thereof, or a hydrate thereof, or a solvate thereof. wherein each symbol is as defined in the specification.

AMINE COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES

A novel amine compound represented by the following formula (I), which is superior in immunosuppressive action, rejection suppressive action and the like, and shows reduced side effects such as bradycardia and the like, or a pharmaceutically acceptable acid addition salt thereof, or hydrates thereof, or solvate, as well as a pharmaceutical composition containing this compound and a pharmaceutically acceptable carrier. wherein R is a hydrogen atom or P(=O)(OH)2, X is an oxygen atom or a sulfur atom, Y is CH2CH2 or CH=CH, R1 is cyano or alkyl having a carbon number of 1 to 4 and substituted by a halogen atom(s), R2 is alkyl having a carbon number of 1 to 4 and optionally substituted by a hydroxyl group(s) or a halogen atom(s), R3 and R4 may be the same or different and each is a hydrogen atom or alkyl having a carbon number of 1 to 4, and n is 5 - 8.