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CAS

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54544-67-1

Isoindolin-5-ol, also known as 5-Hydroxyisoindoline, is an organic compound with the molecular formula C8H7NO. It is a heterocyclic compound featuring a fused indoline ring system with a hydroxyl group at the 5-position. Isoindolin-5-ol serves as a key intermediate in the synthesis of various pharmaceuticals and organic molecules due to its unique structural properties.

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  • 54544-67-1 Structure

  • Basic information

    1. Product Name: Isoindolin-5-ol
    2. Synonyms: I90101;Isoindolin-5-ol;2,3-Dihydro-1H-isoindol-5-ol;ISOINDOLIN-5-OL HBR;1H-Isoindol-5-ol, 2,3-dihydro-
    3. CAS NO:54544-67-1
    4. Molecular Formula: C8H9NO
    5. Molecular Weight: 135.165
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 54544-67-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: Isoindolin-5-ol(CAS DataBase Reference)
    10. NIST Chemistry Reference: Isoindolin-5-ol(54544-67-1)
    11. EPA Substance Registry System: Isoindolin-5-ol(54544-67-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 54544-67-1(Hazardous Substances Data)

54544-67-1 Usage

Uses

Used in Pharmaceutical Industry:
Isoindolin-5-ol is used as a key intermediate in the synthesis of 6-Alkoxyisoindolin-1-one based dopamine D2 partial agonists. These agonists possess potential antipsychotic properties, making them valuable in the development of new treatments for psychiatric disorders.
Used in Organic Synthesis:
Isoindolin-5-ol is also utilized in organic synthesis for the creation of various other compounds with diverse applications. Its unique structure allows for further functionalization and modification, contributing to the development of novel molecules with potential uses in various industries, including pharmaceuticals, agrochemicals, and materials science.

Check Digit Verification of cas no

The CAS Registry Mumber 54544-67-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,4,5,4 and 4 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 54544-67:
(7*5)+(6*4)+(5*5)+(4*4)+(3*4)+(2*6)+(1*7)=131
131 % 10 = 1
So 54544-67-1 is a valid CAS Registry Number.

54544-67-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,3-dihydro-1H-isoindol-5-ol

1.2 Other means of identification

Product number -
Other names Isoindolin-5-ol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:54544-67-1 SDS

54544-67-1Relevant articles and documents

INDAZOLAMIDE DERIVATIVES

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Page/Page column 18, (2010/10/19)

Novel indazole derivatives of the formula (I), in which R1-R3 have the meanings indicated in claim 1, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.

Design and synthesis of novel 2,3-dihydro-1H-isoindoles with high affinity and selectivity for the dopamine D3 receptor

Austin, Nigel E,Avenell, Kim Y,Boyfield, Izzy,Branch, Clive L,Hadley, Michael S,Jeffrey, Phillip,Johnson, Christopher N,Macdonald, Gregor J,Nash, David J,Riley, Graham J,Smith, Alexander B,Stemp, Geoffrey,Thewlis, Kevin M,Vong, Antonio K.K,Wood, Martyn D

, p. 685 - 688 (2007/10/03)

Starting from the tetrahydroisoquinoline SB-2770111, a novel series of 5-substituted-2,3-dihydro-1H-isoindoles has been designed. Subsequent optimisation resulted in identification of 19. which has high affinity for the dopamine D3 receptor (pKi 8.3) and ≥ 100-fold selectivity over other aminergic receptors. In rat studies 19 was brain penetrant with an excellent pharmacokinetic profile (oral bioavailability 77%. t1/2 5.2h).

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