- Solvent and catalyst-free synthesis of imidazo[1,2-a]pyridines by grindstone chemistry
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The present work describes the solvent and catalyst-free synthesis of imidazo[1,2-a]pyridines in excellent to nearly quantitative yields from 2-aminopyridines and a wide variety of ω-bromomethylketones using a grindstone procedure at 25°C to 30°C for 3 to
- Godugu, Kumar,Nallagondu, Chinna Gangi Reddy
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p. 250 - 259
(2020/10/23)
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- A synthetic method of 2-phenyl-imidazo[1,2-a]pyridine compounds
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A synthetic method of 2-phenyl-imidazo[1,2-a]pyridine compounds is disclosed. Compared with the prior art, the method adopts a high-frequency mechanical grinding technique, is finished by a one-step reaction and is simple in operation, free of solvents in a reaction process and free of chemical agents with high toxicity. The method is short in reaction time and mild in reaction conditions, wherein the reaction can be finished in 90 min and can be performed at room temperature with a oscillation frequency of 30 Hz. The method is high in yield, and the highest yield can reach 94%. The method can rapidly and effectively synthesize the 2-phenyl-imidazo[1,2-a]pyridine compounds with strong electron withdrawing groups, while the 2-phenyl-imidazo[1,2-a]pyridine compounds with the strong electron withdrawing groups cannot be synthesized by traditional methods or are low in synthesis yield unless extremely extreme and strict reaction conditions are adopted.
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Paragraph 0048; 0049; 0050; 0051; 0052; 0055
(2016/10/10)
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- Iron(III)-catalyzed three-component domino strategy for the synthesis of imidazo[1,2-a]pyridines
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An efficient, one-pot, three-component domino strategy has been demonstrated for the synthesis of imidazo[1,2-a]pyridines using a catalytic amount of Fe(III) chloride in high yields in air. A library of imidazo[1,2-a]pyridines was synthesized by the reaction of easily available aldehydes and 2-aminopyridines in a mixture of nitroalkane and DMF (2:1). This transformation presumably occurs by a sequential aza-Henry reaction/cyclization/denitration. The use of readily available chemicals as starting materials, inexpensive metal catalyst, aerobic reaction conditions, tolerance of a wide range of functional groups, and operational simplicity are the notable advantages of this present protocol.
- Santra, Sougata,Mitra, Shubhanjan,Bagdi, Avik Kumar,Majee, Adinath,Hajra, Alakananda
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supporting information
p. 5151 - 5155
(2014/12/10)
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- Copper-catalyzed synthesis of imidazo[1,2-a]pyridines through tandem imine formation-oxidative cyclization under ambient air: One-step synthesis of zolimidine on a gram-scale
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A new copper-catalyzed oxidative cyclization via C-H amination between 2-aminopyridines and methyl aryl/heteroaryl ketones has been developed under ambient air. Imidazo[1,2-a]pyridines containing a wide range of functional groups have been synthesized from basic and easily available starting materials. This simple, one-pot reaction protocol is applicable for the direct preparation of zolimidine (a marketed antiulcer drug) on a large scale. Copyright
- Bagdi, Avik Kumar,Rahman, Matiur,Santra, Sougata,Majee, Adinath,Hajra, Alakananda
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supporting information
p. 1741 - 1747
(2013/07/11)
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